摘要
全髋关节置换术(total hip arthroplasty,THA)是治疗影响髋关节骨折、退行性病变的常用方法,临床上髋关节置换术的应用愈加广泛,现已应用于矫形骨科、创伤骨科等多个科室。围手术期失血量是全髋关节置换术患者非常关心的问题,多例随机对照试验和荟萃分析研究表明氨甲环酸(tranexamic acid,TXA)在减少髋关节置换术围手术期失血量和输血需求方面是有效的,且没有增加并发症。然而,氨甲环酸在全髋关节置换术中的给药途径、具体方法、最佳剂量、给药时机、是否放置引流管及引流夹闭后何时开放、药动学研究、安全性及经济性等方面没有确切的定论,仍存在疑问。故本文通过参阅近年来氨甲环酸在全髋关节置换术中的相关研究,做一文献综述。
Total hip arthroplasty(THA)is a commonly used method to treat hip fracture and degenerative diseases.It has been increasingly widely used in clinical practice and has been applied in orthopaedic orthopedics,trauma orthopedics and other departments.Perioperative blood loss is an issue of great concern for patients undergoing total hip arthroplasty.Multiple randomized controlled trials and meta-analysis studies have shown that tranexamic acid(TXA)is effective in reducing perioperative blood loss and blood transfusion requirements of hip arthroplasty without increasing complications.However,there is no definite conclusion on the route of administration,specific method,optimal dose,timing of administration,whether to place the drainage tube and when to open it after drainage clamping,pharmacokinetic study,safety and economy of tranexamic acid in total hip arthroplasty.Therefore,this article reviews the relevant studies of tranexamic acid in total hip arthroplasty in recent years.
作者
杨雅麟
任爽
张威
甄健存
YANG Ya-lin;REN Shuang;ZHANG Wei;ZHEN Jian-cun(Department of Pharmacy,Beijing Jishuitan Hospital,Beijing 100035,China;Department of Pharmacy Administration and Clinical Pharmacy,School of Pharmaceutical Sciences,Peking University,Beijing 100191,China)
出处
《中国医院药学杂志》
CAS
北大核心
2020年第4期456-461,共6页
Chinese Journal of Hospital Pharmacy
关键词
全髋关节置换术
氨甲环酸
研究进展
total hip replacement
tranexamic acid
research progress
