摘要
急性早幼粒细胞白血病(APL)是急性髓系白血病中较特殊亚型,以异常早幼粒细胞增多为主要特征。全反式维A酸、蒽环类药物及三氧化二砷的应用显著提高了APL的缓解率及生存率。但是治疗中部分患者可出现严重不良反应——分化综合征(DS)。DS进展迅速,常可危及生命。然而,DS早期症状缺乏典型性,临床表现与多种疾病相似,极易误诊、漏诊,诊断困难,且有效控制DS的治疗方案仍存在争议。因此,如何早预测、早诊断、有效治疗DS成为一亟待解决的问题。
Acute promyelocytic leukemia(APL)is a special subtype of acute myeloid leukemia characterized by abnormal promyelocytosis.The use of all-trans retinoic acid,anthracyclines and arsenic trioxide has significant improved the remission and survival rate of APL.However,some patients may experience a serious adverse reaction-differentiation syndrome(DS).DS progresses rapidly and can often be life-threatening.However,the early symptoms of DS is less typical,and the clinical manifestations are similar to a variety of diseases,which may easily result in misdiagnosis and miss diagnosis,making diagnosis difficult.What′s more,the effective control of DS treatment is controversial.Therefore,how to early predict,diagnose and effectively treat DS has become an urgent problem.
作者
钟琳
刘琳
周泽平
ZHONG Lin;LIU Lin;ZHOU Zeping(Department of Hematology,the Second Affiliated Hospital of Kunming Medical University,Kunming 650101,China)
出处
《医学综述》
2020年第7期1374-1378,共5页
Medical Recapitulate
