摘要
目的:探讨心脉隆注射液对慢性心力衰竭患者心功能及炎性因子的影响。方法:选取2016年3月—2019年2月南阳市中心医院重症医学科收治的100例符合纳入和排除标准的慢性心力衰竭患者为研究对象,随机分为研究组和对照组各50例,对照组患者采取常规抗心力衰竭治疗,研究组患者在对照组治疗基础上给予心脉隆注射液,均连续治疗14d后观察疗效。对比两组患者左心室射血分数(Left ventricular ejection fractions,LVEF)、左心室舒张末期内径(Left ventricular end diastolic diameter,LVDd)和超敏C反应蛋白(Hypersensitive C-reactive protein,hs-CRP)、白介素-10(Interleukin-10,IL-10)和白介素-18(Interleukin-18,IL-18)水平变化。结果:治疗前两组患者LVEF、LVEd值比较无统计学意义(P<0.05);治疗后两组患者LVEF、LVEd值均优于治疗前,研究组LVEF值高于对照组,LVDd值低于对照组(P<0.05);治疗后研究组患者hs-CRP、IL-18水平均低于对照组,IL-10水平高于对照组(P<0.05);研究组患者的总有效率为96.00%,明显高于对照组患者的80.00%(P<0.05)。结论:心脉隆注射液能够抑制慢性心力衰竭患者的免疫炎症反应,同时改善患者微循环和心功能,减轻心脏前后负荷,疗效显著,安全性高,具有临床应用价值。
Objective:To investigate the effects of Xinmailong injection on cardiac function and inflammatory factors in patients with chronic heart failure.Methods:A total of 100 patients with chronic heart failure who met the inclusion and exclusion criteria from March 2016 to February 2019 in the Department of Critical Medicine of Nanyang Central Hospital were randomly divided into a study group and a control group of 50 cases each.Patients in the group were treated with conventional anti-heart failure.Patients in the study group were given Xinmailong injection on the basis of treatment in the control group.The efficacy was observed after 14 days of continuous treatment.The left ventricular ejection fractions(LVEF),left ventricular end diastolic diameter(LVDd),and hypersensitive C-reactive protein(hs CRP)of the two groups of patients were compared.Interleukin-10(IL-10)and interleukin-18(IL-18)levels changed.Results:The LVEF and LVEd values of the two groups of patients before treatment were not statistically significant(P<0.05);the LVEF and LVEd values of the two groups of patients after treatment were better than before treatment.Control group(P<0.05);hs-CRP and IL-18 levels in the study group were lower than those in the control group,and IL-10 levels were higher than those in the control group(P<0.05);the total effective rate of the study group patients was 96.00%,Which was significantly higher than 80.00%of patients in the control group(P<0.05).Conclusion:Xinmailong injection can inhibit the immune inflammatory response in patients with chronic heart failure,improve the microcirculation and heart function,reduce the preand post-load of the heart,has significant curative effect,high safety,and has clinical application value.
作者
周小超
徐琳
ZHOU Xiaochao;XU Lin(Nanyang Central Hospital,Henan Nanyang 473000,China)
出处
《中医药临床杂志》
2020年第2期344-346,共3页
Clinical Journal of Traditional Chinese Medicine
基金
安徽省卫生厅中医药科研计划资助项目(NO.2012zy97)。
关键词
心脉隆注射液
慢性心力衰竭
心功能
炎性因子
Xinmailong injection
Chronic heart failure
Heart function
Inflammatory factors
