摘要
目的:探讨总胆汁酸、甘胆酸水平联合脐动脉血流对妊娠期肝内胆汁淤积症(ICP)孕妇孕期管理和妊娠结局的评估价值。方法:选取2016年5月-2019年5月在广州市增城区妇幼保健院妇产科住院并分娩的ICP患者共98例(ICP组)。选取同期常规检查健康的孕妇80例(对照组)。比较两组血清总胆汁酸、甘胆酸水平;彩色多普勒超声仪测定研究对象的脐动脉血流的收缩末期峰值/舒张末期峰值(S/D)比值;ICP患者入院后予以护肝降酶、补充营养物质、维生素C等常规治疗,比较治疗前后血清总胆汁酸、甘胆酸和S/D水平。详细记录在分娩后新生儿窒息、早产、胎儿宫内窘迫、羊水粪染的发生情况。对ICP孕妇血清总胆汁酸、甘胆酸、S/D与上述妊娠结局指标的相关性进行分析。结果:ICP组血清总胆汁酸、甘胆酸、S/D水平明显高于对照组(P<0.01);常规治疗后,ICP孕妇血清总胆汁酸、甘胆酸、S/D水平显著降低(P<0.01);ICP组孕妇的新生儿窒息、早产、胎儿宫内窘迫、羊水粪染的发生率均明显高于对照组(P<0.05);ICP患者血清总胆汁酸、甘胆酸和S/D水平与新生儿窒息、早产、胎儿宫内窘迫、羊水粪染均呈正相关(P<0.01)。结论:总胆汁酸、甘胆酸测定联合脐动脉血流对ICP患者的孕期管理及妊娠结局有重要临床价值。
Objective:To investigate the value of total bile acid and glyceric acid combined with umbilical artery blood flow in pregnancy management and pregnancy outcome of intrahepatic cholestasis of pregnancy(ICP).Method:Ninety-eight ICP patients had hospital stay and delivery in department of obstetrics and gynecology of Zengcheng District Maternal and Child Health Care Hospital in Guangzhou from May 2016 to May 2019 were collected as the ICP group.A total of 80 healthy pregnant women with routine examination during the same period were selected as control group.Serum levels of total bile acid and glycine acid were compared between two groups.The color doppler ultrasound was employed to detect the ratio of end-systolic peak/end-diastolic peak(S/D)of blood flow in umbilical artery.After admission,ICP patients were routinely treated with liver protection and enzyme lowering,nutrient supplementation and vitamin C,and the serum total bile acid,glycine acid,and S/D were compared before and after treatment.The incidence of neonatal asphyxia,preterm delivery,fetal distress,and amniotic fluid fecal contamination were recorded.The correlation of serum total bile acid,glycine acid,and S/D with these pregnancy outcome indicators in ICP patients was analyzed.Result:Serm levels of total bile acid,glyceric acid,and S/D in the ICP group were significantly higher than those in the control group(P<0.01).After routine treatment,levels of total bile acid and glycine acid in serum,and S/D were obviously decreased in ICP patients(P<0.01).The incidence of neonatal asphyxia,preterm delivery,fetal distress and amniotic fluid fecal contamination in the ICP group was obviously higher than those in the control group(P<0.05).Levels of total bile acid and glycine acid in serum and S/D levels in ICP patients were positively correlated with these pregnancy outcome indicators(P<0.01).Conclusion:The measurement of total bile acid and glyceric acid combined with umbilical artery blood flow have an important clinical value in pregnancy management and pre
作者
单款玲
钟达财
肖杰文
李娲
SHAN Kuanling;ZHONG Dacai;XIAO Jiewen;LI Wa(Zengcheng District Maternal and Child Health Hospital in Guangzhou,Guangzhou 511300,China;不详)
出处
《中外医学研究》
2020年第6期47-49,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
妊娠肝内胆汁淤积症
总胆汁酸
甘胆酸
脐动脉血流
妊娠结局
Intrahepatic cholestasis of pregnancy
Total bile acid
Glyceric acid
Umbilical artery blood flow
Pregnancy outcome
