摘要
目的观察何氏育麟方联合中药督脉熏蒸治疗肾虚血瘀型反复着床失败(recurrent implantation failure,RIF)患者的临床疗效,并探讨其对患者临床妊娠率、胚胎种植率、激素水平、子宫动脉血流的影响。方法选取62例2017年2月-2018年9月期间就诊于宁波市妇女儿童医院的肾虚血瘀型RIF患者作为研究对象,采用随机数表法,分成对照组和观察组,各31例,2组年龄、病程等一般资料比较,差异无统计学意义(均P>0.05),具有可比性。对照组患者单纯给予阿司匹林肠溶片口服治疗,每片25 mg,每次1片,3次/d。观察组患者予何氏育麟方每天1剂,水煎服,早晚各一煎,每煎200 mL;联合中药督脉熏蒸治疗,隔日熏蒸1次。2组患者均连续治疗3个月经周期。对比2组患者治疗后的临床效果,计算临床妊娠率、胚胎种植率,监测黄体中期2组患者的血激素水平、子宫内膜厚度、子宫动脉血流。结果观察组的临床妊娠率为51.61%,与对照组(25.81%)相比明显升高;观察组的胚胎种植率为31.67%,与对照组的15.25%相比明显升高;观察组患者黄体中期的血雌二醇(E2)、黄体酮(P)水平、子宫B超情况明显优于对照组,以上差异均有统计学意义(均P<0.05)。结论何氏育麟方联合中药督脉熏蒸有利于提高肾虚血瘀型RIF患者的临床妊娠率和胚胎种植率,疗效确切,这与二者协同使用可改善子宫内膜容受性、降低子宫动脉血流阻力、调控激素水平、改善内分泌密切相关。
Objective Observe the clinical efficacy of Heshi Yulin Recipe combined with traditional Chinese medicine fumigation treatment for recurrent implantation failure(RIF) of kidney deficiency and blood stasis type, and to explore its influence on patients ’ clinical pregnancy rate, embryo implantation rate, hormone level and uterine artery flow. Methods A total of 62 patients who were diagnosed as RIF of kidney deficiency and blood stasis type in Ningbo Women and Children’s Hospital from February 2017 to September 2018 were divided into control group and observation group by random number table method with 31 cases each group. There was no statistically difference significant in basic information between two groups(P>0.05). The patients in the control group were given only oral treatment with aspirin enteric-coated tablets for 3 times a day, 1 tablet each time and 25 mg per tablet. The patients in the observation group were given treatment combining water decoction of Heshi Yulin Recipe for one potion per day, two times on each morning and evening, 200 mL per time, and once every other day with traditional Chinese medicine fumigation. All patients were treated continuously for 3 menstrual cycles. The clinical effects after treatment of the two groups were compared. The clinical pregnancy rate, embryo implantation rate, monitored the blood hormone levels, endometrial thickness and type, and uterine artery blood flow in mid-secretory phase were calculated. Results The clinical pregnancy rate of the observation group was 51.61%, which was obviously higher than that of the control group(25.81%), P<0.05. The embryo implantation rate of the observation group was 31.67%, which was obviously higher than that of the control group(15.25%), P<0.05. The blood estradiol E2, P level and uterine B-ultrasound of the observation group were significantly better than those in the control group(all P<0.05). Conclusion Heshi Yulin Recipe combined with traditional Chinese medicine fumigation has exact curative effect, it is beneficial
作者
黄月颖
田蕾
陈忠菊
HUANG Yue-ying;TIAN Lei;CHEN Zhong-ju(Traditional Chinese Medicine Department,Ningbo Women&Children's Hospital,Ningbo,Zhejiang 315012,China)
出处
《中华全科医学》
2020年第3期484-487,共4页
Chinese Journal of General Practice
基金
浙江省中医药科技计划项目(2019ZA115)。
关键词
肾虚血瘀型
反复着床失败
何氏育麟方
中药督脉熏蒸
Kidney deficiency and blood stasis type
Recurrent implantation failure
Heshi Yulin Recipe
Traditional Chinese medicine fumigation treatment
