摘要
妊娠期糖尿病(gestational diabetes mellitus,GDM)是指妊娠前无糖尿病病史的女性在妊娠期间诊断出的糖耐量异常,可对孕妇及胎儿的围产期以及远期健康造成不良影响.近年来,GDM的发病率不断升高,但是GDM的病因和发病机制尚不完全清楚.越来越多的研究表明,GDM的发生发展与遗传易感性相关.因此,本文就GDM易感基因的最新研究进展进行综述.
Gestational diabetes mellitus(GDM)refers to abnormal glucose tolerance that is firstly diagnosed during pregnancy in women without a history of diabetes before pregnancy,which may cause adverse effects on the perinatal and long-term health of pregnant women and fetuses.In recent years,the incidence of GDM has been increasing,whereas the etiology and pathogenesis of GDM are not fully understood.More and more studies have shown that the occurrence and development of GDM is related to genetic susceptibility.Therefore,this article reviews the latest research advance of susceptibility genes associated with GDM.
作者
魏文文
王欣
谭贵琴
周芳宇
杜娟
于红松
WEI Wen-wen;WANG Xin;TAN Gui-qin;ZHOU Fang-yu;DU Juan;YU Hong-song(School of Basic Medical Science,Special Key Laboratory of Gene Detection&Therapy of Guizhou Province,Zunyi Medical University,Zunyi 563000,China)
出处
《聊城大学学报（自然科学版）》
2020年第3期105-110,共6页
Journal of Liaocheng University:Natural Science Edition
基金
国家重点研发计划项目(2018YFC1004303)
国家自然科学基金面上项目(81670844)
贵州省科学基金重点项目(黔科合基础[2019]1464)
贵州省普通高等学校科技拔尖人才支持计划项目(黔教合KY字[2017]077)
遵义医科大学优秀青年人才计划(18-ZY-001).
关键词
妊娠期糖尿病
易感基因
单核苷酸多态性
研究进展
gestational diabetes mellitus
susceptibility genes
single nucleotide polymorphism
research advance
