摘要
绦虫是常见的人兽共感染寄生虫。绦虫排泄分泌物(ESP)是绦虫在感染过程中分泌/排泄并直接暴露于宿主免疫系统的产物,是最可能引起宿主免疫效应变化的原因之一。近年来大量研究显示,该物质可诱导和调控宿主的免疫应答,与绦虫感染密切相关。绦虫ESP可诱导宿主产生正向免疫效应来控制感染,亦可诱导宿主产生负向免疫效应,从而逃避宿主的免疫攻击,建立长期感染。本文对绦虫ESP与宿主免疫效应的相关研究作一简要综述。
Cestodes are common zoonotic parasites.The excretory/secretory products(ESPs) of cestodes are produced during the infection and exposed directly to the host immune system,being one of the most possible effectors causing the changes of host immune responses.In recent years,a wealth of studies have shown that ESPs can induce and regulate the host immune responses,which are closely related to the cestodes infection.Cestodes ESPs can induce host ’ s positive immune response to control the infection,and also induce negative immune response,enabling the cestodes to evade the host immune attacks.thus resulting in establishment of a long-time infection.This paper presents a brief review on the relations between cestode ESPs and host immune response.
作者
范贤敏
周必英
FAN Xian-min;ZHOU Bi-ying(Department of Parasitology,Zunyi Medical University,Zunyi 563000,China)
出处
《中国寄生虫学与寄生虫病杂志》
CAS
CSCD
北大核心
2020年第1期128-132,F0003,共6页
Chinese Journal of Parasitology and Parasitic Diseases
基金
国家自然科学基金(No.81960378)
贵州省优秀青年科技人才培养资助项目(黔科合平台人才[2017]5629)
省市科技合作专项资金项目(省市科合[2015]52)。
关键词
绦虫
排泄分泌物
免疫效应
Cestode
Excretory/secretory product
Immunological effect
