摘要
急性髓细胞白血病(AML)存在的高复发率、高病死率及耐药性等问题,为目前需要攻克的主要难关及研究相关热点。多项研究结果证实,外泌体源性微小RNA(miRNA)在AML发病过程中发挥重要作用,包括对骨髓微环境的调控,参与AML肿瘤血管的形成,以及参与耐药的发生等。因此,针对AML中外泌体源性miRNA的相关研究,将为提高AML患者预后及克服耐药提供新的研究方向。笔者拟就外泌体源性miRNA在AML中的相关作用及其介导AML的耐药机制等方面进行介绍。
Acute myeloid leukemia(AML)has a high recurrence rate,high case fatality rate and drug resistance,which are major problems to be solved and a research hotspot.A number of researches confirmed that exosome-derived microRNA(miRNA)plays an important role in the disease process,such as the regulation of bone marrow microenvironment,formation of tumor blood vessels in AML,and participating in the occurrence of drug resistance.So for exosome-derived miRNA related researches in AML provide the new research direction to improve the prognosis of patients with AML and overcome drug resistance.The article intends to introduce the related role of exosome-derived miRNA in AML and the drug resistance mechanism of AML mediated by them.
作者
何哲炜
郭文坚
He Zhevuei;Guo Wenjian(Department of Hematology and Oncology,the Second Affiliated Hospital of Wenzhou Medical University,Wenzhou 325000,Zhejiang Province,China)
出处
《国际输血及血液学杂志》
CAS
2020年第1期23-26,共4页
International Journal of Blood Transfusion and Hematology
基金
温州市科技局科技计划项目(Y20170048)。
关键词
白血病
髓样
急性
外泌体
微小RNA
抗药性
肿瘤
肿瘤微环境
Leukemia
myeloid
acute
Exosomes
MicroRNAs
Drug resistance
neoplasm
Tumor microenvironment
