摘要
目的评价氨溴索雾化吸入治疗老年慢性支气管炎的疗效及安全性。方法计算机检索Cochrane Library、EMbase、Pub Med、中国生物医学文献数据库、维普中文期刊数据库、中国知网和万方数据,纳入氨溴索雾化对比氨溴索常规治疗老年慢性支气管炎的随机对照试验(RCT),对纳入的研究进行方法学质量评价和Meta分析。结果共纳入24篇研究,合计3374例患者。Meta分析结果显示,氨溴索雾化吸入组在治疗老年慢性支气管炎疾病的有效率[OR=5.51,95%CI(4.35,6.99)]、治疗后咳嗽咳痰缓解时间[MD=-2.30,95%CI(-2.47,-2.12)]、体温恢复时间[MD=-1.45,95%CI(-2.28,-0.61)]、住院天数[MD=-1.83,95%CI(-1.98,-1.69)]均优于氨溴索常规治疗组,差异有统计学意义(P<0.001)。结论氨溴索雾化吸入治疗老年慢性支气管炎疗效较好,但缺乏不良反应资料,其应用的安全性存在一定风险,仍需更多设计完善的多中心的随机双盲对照试验进行论证。
Objective To evaluate the efficacy and safety of aerosol inhalation of ambroxol in the treatment of chronic bronchitis in the elderly.Methods Cochrane Library,EMbase,PubMed,CBM,VIP,CNKI and Wanfang Data were searched to collect the randomized controlled trials(RCT) of ambroxol atomization versus ambroxol in the treatment of chronic bronchitis in the elderly.Methodological quality evaluation and meta-analysis were performed by trials.Results A total of 24 trials were included,involving3374 patients.The results of meta-analysis showed that,the effective rate of treatment of chronic bronchitis in the elderly [OR=5.51,95%CI(4.35,6.99),P<0.001],cough and cough relief time after treatment [MD=-2.30,95%CI(-2.47,-2.12),P<0.001],body temperature recovery time [MD=-1.45,95% CI(-2.28,-0.61),P<0.001] and hospitalization days [MD=-1.83,95% CI(-1.98,-1.69),P<0.001] of the ambroxol aerosol inhalation group was all superior to the ambroxol conventional treatment group.Conclusion The efficacy of ambroxol aerosol inhalation in treating chronic bronchitis in the elderly is superior to ambroxol.Due to the lack of data of adverse reaction,there is a certain risk in the safety of its application.More randomized,double-blind and controlled trial of the center studies are needed.
作者
黄利民
张炜
孙兆瑞
杨志洲
任艺
聂时南
HUANG Li-min;ZHANG Wei;SUN Zhao-rui;YANG Zhi-zhou;REN Yi;NIE Shi-nan(Department of Emergency Medicine,General Hospital of Eastern Theater Command,PLA,Nanjing 210002,Jiangsu,China)
出处
《东南国防医药》
2020年第2期165-171,共7页
Military Medical Journal of Southeast China
关键词
氨溴索
雾化吸入
老年慢性支气管炎
系统评价
ambroxol
aerosol inhalation
elderly chronic bronchitis
system assesment
