摘要
目的研究尿酸(UA)、高密度脂蛋白胆固醇(HDL-C)、载脂蛋白A1与高密度脂蛋白比值(ApoA1/HDL)在不同帕金森亚型中的表达差异及其与认知功能的相关性。方法选取该院2016年10月至2018年10月门诊治疗的100例老年帕金森患者,针对不同的帕金森疾病患者的一般资料及认知功能障碍之间的差异进行对比,同时对比不同帕金森亚型患者及不同认知障碍情况患者血清UA、HDL-C、ApoA1/HDL之间的差异,分析血清UA、HDL-C、ApoA1/HDL水平与患者认知功能之间的相关性。结果不同帕金森亚型患者的性别、年龄、体质量指数之间的差异无统计学意义(P>0.05),而不同亚型帕金森患者的简易智能精神状态检查量表(MMSE)评分、蒙特利尔认知评估量表(MoCA)评分之间的差异有统计学意义(P<0.05);不同亚型帕金森患者的血清UA、HDL-C、ApoA1/HDL水平及不同认知情况的帕金森患者的血清UA、HDL-C、ApoA1/HDL水平之间的差异有统计学意义(P<0.05)。结论帕金森患者的认知功能与血清UA、HDL-C、ApoA1/HDL水平呈负相关,且随着帕金森患者合并临床症状的不断累积,其UA、HDL-C、ApoA1/HDL水平显著下降。
Objective To study the expression differences of uric acid(UA),high density lipoprotein cholesterol(HDL-C)and apolipoprotein A1(ApoA1)/high density lipoprotein(HDL)in different Parkinson subtypes and their correlation with cognitive function.Methods 100 elderly patients with Parkinson′s disease who were treated in our hospital from October 2016 to October 2018 were selected.The general data of different patients with Parkinson′s disease and the differences of cognitive impairment were compared.The differences of serum UA,HDL-C,ApoA1/HDL between different patients with Parkinson′s subtype and patients with different cognitive impairment were compared.The levels of serum UA,HDL-C and ApoA1/HDL were analyzed.Relevance with patients′cognitive function.Results There were no significant differences in gender,age and body mass index between different Parkinson′s subtypes(P>0.05),but there were significant differences in MMSE and MoCA scores between different Parkinson′s subtypes(P<0.05);serum UA,HDL-C,ApoA1/HDL levels and different cognitive status of Parkinson′s patients and different subtypes of Parkinson′s disease(P<0.05).Conclusion The cognitive function of Parkinson′s patients is negatively correlated with serum UA,HDL-C and ApoA1/HDL levels.With the accumulation of clinical symptoms,the levels of UA,HDL-C and ApoA1/HDL in Parkinson′s patients decrease significantly.
作者
杨晓丽
黄晓勇
YANG Xiaoli;HUANG Xiaoyong(Department of Neurology,Haian People′s Hospital Affiliated to Nantong University,Nantong,Jiangsu 226600,China)
出处
《国际检验医学杂志》
CAS
2020年第6期724-727,共4页
International Journal of Laboratory Medicine
关键词
帕金森
尿酸
认知功能障碍
高密度脂蛋白胆固醇
载脂蛋白A1
高密度脂蛋白
Parkinson
uric acid
cognitive impairment
high density lipoprotein cholesterol
apolipoprotein A1
high density lipoprotein ratio
