摘要
目的探讨高频振荡通气(high frequency oscillatory ventilation,HFOV)叠加常频通气(constant frequency ventilation,CMV)联合西地那非、注射用牛肺表面活性剂治疗重度新生儿持续性肺动脉高压(persistent pulmonaryhypertension of newborn,PPHN)的临床效果。方法选取重度PPHN患儿86例,按照随机数字表法分为研究组和对照组各43例,对照组给予西地那非、CMV治疗,研究组给予HFOV叠加CMV联合西地那非,注射用牛肺表面活性剂治疗。比较2组患儿治疗前及治疗后6,12,24,36 h的氧合指数(oxygenation index,OI)、血氧饱和度(oxygen saturation of blood,SpO 2),治疗相关指标及治疗疗效。结果研究组治疗后各时点的OI明显低于对照组,研究组治疗后12,24,36 h的SpO 2明显高于对照组,差异有统计学意义(P<0.01)。各组治疗后不同时点的OI与治疗前比较明显降低,研究组治疗后各时点的SpO 2与治疗前比较明显升高,对照组治疗后36 h的SpO 2与治疗前比较明显升高,差异有统计学意义(P<0.01)。研究组的吸氧时间、呼吸机使用时间、住院时间、住院费用明显少于对照组,差异有统计学意义(P<0.01)。研究组治疗总有效率明显高于对照组,差异有统计学意义(P<0.05)。结论HFOV叠加CMV联合西地那非,注射用牛肺表面活性剂治疗重度PPHN患儿,可有效改善肺氧合功能,减少呼吸机使用时间、氧疗时间,提高治疗疗效。
Objective To investigate the clinical effects of high frequency oscillatory ventilation(HFOV)combined with normal frequency ventilation(CMV)combined with Sildenafil and colisulla on severe neonatal persistent pulmonary hypertension(PPHN).Methods A total of 86 children with severe PPHN were selected and divided into a study group and a control group with 43 cases each according to the random number table method.The control group was treated with sildenafil and CMV treatment.The oxygenation index(OI),oxygen saturation of blood(SpO 2),treatment-related indexes,and treatment efficacy were compared between patients of two groups before and 6 h,12 h,24 h,36 h after treatment.Results The OI of the study group was significantly lower than that of the control group at each time point after treatment.The SpO 2 at 12 h,24 h and 36 h after treatment was significantly higher in the study group than in the control group(P<0.01).The OI at different time points after treatment was significantly lower than that before treatment.The SpO 2 at each time point after treatment was significantly higher than that before treatment.The SpO 2 at 36 h after treatment was significantly higher than that before treatment with statistical significance(P<0.01).The oxygen inhalation time,ventilator use time,hospitalization time,and hospitalization cost of the study group were significantly lower than those of the control group,and the difference was statistically significant(P<0.01).The total effective rate of the study group was significantly higher than that of the control group,the difference was statistically significant(P<0.05).Conclusion Sildenafil combined with calsurf and HFOV superimposed CMV in children with heavy negative PPHN can effectively improve pulmonary oxygenation,reduce ventilator use time,oxygen therapy time and improve treatment efficacy.
作者
杨海娟
许泽辉
张梦华
YANG Hai-juan;XU Ze-hui;ZHANG Meng-hua(Department of Pediatric,Langfang People′s Hospital,Hebei Province,Langfang 065000,China;Department of Ultrasound,Langfang People′s Hospital,Hebei Province,Langfang 065000,China)
出处
《河北医科大学学报》
CAS
2020年第3期315-318,共4页
Journal of Hebei Medical University
基金
廊坊市科学技术研究与发展计划(2016013180)。
关键词
高血压
肺性
胸壁震荡通气
西地那非
hypertension
pulmonary
chest wall oscillation
sildenafil
