摘要
目的分析慢阻肺急性加重期患者采用糖皮质激素联合特布他林治疗的临床疗效。方法选取2017年1月—2019年1月期间在该院就诊的60例慢阻肺急性加重期患者,按照随机抽签法分为实验组(30例,采用糖皮质激素联合特布他林治疗)和对照组(30例,仅仅采用特布他林治疗),对比两组患者治疗效果、治疗前后1 s用力呼气容积(FEV1)、用力肺活量(FVC)、用力呼气量占用力肺活量比值(FEV1/FVC)等肺功能指标变化以及动脉血二氧化碳分压(PaCO2)、血氧分压(PaO2)等血气指标变化。结果实验组患者治疗总有效率96.7%显著高于对照组76.7%(χ^2=12.503,P<0.05)。两组患者治疗后FEV1、FVC、FEV1/FVC等肺功能指标均优于治疗前(P<0.05),但实验组患者治疗后FEV1、FVC、FEV1/FVC等肺功能指标更优于对照组(P<0.05)。两组患者治疗后PaCO2指标均低于治疗前(P<0.05),PaO2指标均高于治疗前(P<0.05),但实验组患者治疗后PaCO2、PaO2指标更优于对照组(P<0.05)。结论慢阻肺急性加重期患者采用糖皮质激素联合特布他林治疗的临床疗效良好,可有效改善患者血气指标,提高患者肺功能,可在临床上广泛推广应用。
Objective To analyze the clinical efficacy of glucocorticoid combined with terbutaline in patients with acute exacerbation of chronic obstructive pulmonary disease.Methods 60 patients with acute exacerbation of chronic obstructive pulmonary disease who were admitted to the hospital from January 2017 to January 2019 were enrolled in the experimental group(30 patients were treated with glucocorticoid plus terbutaline)and the control group(30 cases,only treated with terbutaline),compared the treatment effect of the two groups of patients,forced expiratory volume(FEV1),forced vital capacity(FVC),forced expiratory volume and vital capacity ratio before and after treatment(changes in lung function indexes such as FEV1/FVC)and changes in blood gas indexes such as arterial blood carbon dioxide partial pressure(PaCO2)and blood oxygen partial pressure(PaO2).Results The total effective rate of the experimental group was 96.7%,which was significantly higher than that of the control group(76.7%)(χ^2=12.503,P<0.05).The lung function indexes of FEV1,FVC and FEV1/FVC were better than those before treatment(P<0.05),but the lung function indexes of FEV1,FVC and FEV1/FVC were better in the experimental group than in the control group(P<0.05).The PaCO2 index of the two groups was lower than that before treatment(P<0.05),and the PaO2 index was higher than that before treatment(P<0.05),but the PaCO2 and PaO2 indexes of the experimental group were better than the control group(P<0.05).Conclusion The patients with acute exacerbation of chronic obstructive pulmonary disease have good clinical efficacy with glucocorticoid combined with terbutaline,which can effectively improve the blood gas index and improve the lung function of patients.It can be widely applied in clinic.
作者
李芳芳
LI Fang-fang(Department of Respiratory,First People's Hospital of Guannan County,Lianyungang,Jiangsu Province,222500 China)
出处
《系统医学》
2020年第1期62-64,共3页
Systems Medicine
关键词
糖皮质激素
特布他林
联合治疗
Glucocorticoid
Terbutaline
Combination therapy
