摘要
目的:讨论酸枣仁汤加减治疗维持性血液透析患者睡眠障碍的临床疗效。方法:资料选取时间为:2018年1月-2019年6月。观察对象为:本院收治50例接受维持性血液透析治疗的终末期肾脏病患者,将其以随机法分为对照组(西药治疗)与研究组(酸枣仁汤加减治疗),各25例。评判标准:匹兹堡睡眠质量指数(PAQI)评分、中医证候积分、血浆5-羟色胺(5-hydroxytryptamine,5-HT)、褪黑素(Melatonin,MT)水平。结果:两组患者治疗前的PAQI评分无明显差异,P>0.05;研究组患者治疗后的PAQI评分指标明显低于对照组,P<0.05。两组患者治疗前的各项中医证候积分无明显差异,P>0.05;研究组患者治疗后的各项中医证候积分指标明显低于对照组,P<0.05。两组患者治疗前的血浆5-HT、MT水平无明显差异,P>0.05;研究组患者治疗后的血浆5-HT、MT水平明显高于对照组,P<0.05。结论:与西药治疗相比,酸枣仁汤加减治疗的实施可有效改善患者的睡眠质量以及各项睡眠中医证候积分,提高其血浆5-HT、MT水平,值得推广。
Objective:To discuss the clinical efficacy of the Suanzaoren decoction(酸枣仁汤)on sleep disorders in patients with maintenance hemodialysis.Methods:50 patients were randomly divided into the control group(received western medicine)and study group(given the Suanzaoren decoction),25 cases in each.Results:The PAQI scores in the study group were significantly lower than the control group,P<0.05.The scores of TCM syndromes in the study group were significantly lower than the control group,P<0.05.The plasma 5-HT and MT levels in the study group were significantly higher than the control group(P<0.05).Conclusion:The Suanzaoren decoction can effectively improve the sleep quality and various sleep TCM symptom scores,and improve plasma 5-HT and MT levels,is worth promoting.
出处
《中医临床研究》
2020年第1期103-105,共3页
Clinical Journal Of Chinese Medicine
关键词
酸枣仁汤
维持性血液透析
睡眠障碍
The Suanzaoren decoction
Maintenance hemodialysis
Sleep disorders
