摘要
阐述了粉末直接压片工艺制备川芎口崩片并对其质量进行评价。采用正交设计优化考察处方中各辅料之间的比例,根据优化后的处方制备川芎口崩片。以阿魏酸为指标,建立了高效液相色谱法对片剂的质量进行评价,方法学验证显示本检测方法专属性高,重复性好。
The preparation and quality evaluation of Ligusticum chuanxiong orally disintegrating tablets by powder direct compression were described.The orthogonal design was used to optimize the proportion of the excipients in the prescription,and Ligusticum chuanxiong orally disintegrating tablets were prepared according to the optimized prescription.With ferulic acid as the index,a HPLC method was established to evaluate the quality of tablets.The development of methodology shows that this method has high specificity and good repeatability.
作者
范谋寅
王渠
洪俊浩
杨仕英
李灏帆
李传旭
肖莉
Fan Mouyin;Wang Qu;Hong Junhao;Yang Shiying;Li Haofan;Li Chuanxu;Xiao Li(College of Life Sciences,Huzhou University,Huzhou313000,China)
出处
《山东化工》
CAS
2020年第4期10-11,共2页
Shandong Chemical Industry
基金
浙江省重点研发项目(2019C02024)
湖州师范学院求真学院大学生创新创业训练项目(201902052)。
关键词
川芎
口崩片
制备
含量测定
Ligusticum chuanxiong
orally disintegrating tablets
preparation
content determination
