摘要
目的:观察"六郁同治法"组方胰岛康Ⅱ号治疗肥胖型糖尿病前期的临床疗效,并分析其可能作用机制。方法:144例肥胖型糖尿病前期患者按随机数字表法分为治疗组与对照组各72例。对照组采用标准化糖尿病健康教育、饮食控制及运动疗法;治疗组在对照组基础上予以胰岛康Ⅱ号胶囊,每次6粒,口服,每日3次,两组疗程均为12周。比较两组患者治疗前后的体质量指数(body mass index,BMI)、糖化血红蛋白(glycosylated hemoglobin,HbA1c)、总胆固醇(total cholesterol,TC)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)、低密度脂蛋白胆固醇(low density lipoprotein cholesterin,LDL-C)、三酰甘油(triacylglycerol,TG)、空腹血糖(fasting blood-glucose,FBG)、空腹胰岛素(fasting insulin,FINS)、餐后2小时血糖(2 hours postprandial blood glucose,2hPBG)、2hINS、胰岛素抵抗指数(insulin resistance index,IRI)、胰岛β细胞功能指数、白细胞介素6(interleukin-6,IL-6)、肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)、瘦素、脂联素。结果:治疗后,治疗组患者BMI、FBG、2hPBG及HbA1c水平较对照组下降更明显(P<0.05);治疗组TC、TG、LDL-C和HDL-C的改善情况优于对照组(P<0.05);治疗组的FINS、2hINS、IRI均低于对照组(P<0.05);治疗组胰岛β细胞功能指数明显高于对照组(P<0.05);治疗组患者IL-6、TNF-α、瘦素水平均低于对照组(P<0.05);治疗组脂联素高于对照组(P<0.05)。结论:"六郁同治法"组方胰岛康Ⅱ号治疗前期肥胖型糖尿病临床疗效显著,能够纠正患者的糖、脂代谢紊乱,改善患者的胰岛素抵抗及胰岛β细胞功能,其作用机制可能与调节IL-6、TNF-α、瘦素及脂联素等因子水平相关。
Objective:To observe the clinical efficacy of"Liuyu Tongzhi method"formulated Yidao KangⅡin the treatment of Obesity pre-diabetes,and to analyze its possible mechanism of action.Methods:144 cases of pre-diabetes were divided into treatment group and control group with 72 cases in each group according to the random number table.The control group was treated with standardized diabetes health education,diet control and exercise therapy;the treatment group was treated with Yidao KangⅡcapsule,6 capsules per time,3 times a day,for 12 weeks.The body mass index(BMI),glycosylated hemoglobin(HbA1 c),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),triacylglycerol(TG),fasting blood-glucose(FBG),fasting insulin(FINS),2 hours postprandial blood glucose(2 hPBG),2 hINS,insulin resistance index(IRI),isletβcell function index,interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),leptin and adiponectin were compared before and after treatment.Results:After treatment,the levels of BMI,FBG,2 hPBG and HbA1 c in the treatment group were significantly lower than those in the control group(P<0.05);the improvement of TC,TG,LDL-C and HDL-C in the treatment group was better than that in the control group(P<0.05);the FINS,2 hINS and IRI in the treatment group were lower than those in the control group(P<0.05);the isletβcell function index in the treatment group was significantly higher than that in the control group(P<0.05);the levels of IL-6,TNF-αand leptin in the treatment group were all higher than those in the control group(P<0.05);the level of adiponectin in the treatment group was higher than that in the control group(P<0.05).Conclusion:The clinical efficacy of"Liuyu Tongzhi method"formulated Yidao KangⅡin the treatment of Obesity pre-diabetes is significant.It can correct the disorder of glucose and lipid metabolism,improve the insulin resistance and isletβcell function of the patients.Its mechanism may be related to the regulation of IL-6,TNF-α,leptin,adiponectin
作者
莫小书
周月红
廖尚上
荣三群
姜艳
刘敏
胡文孝
常九州
MO Xiaoshu;ZHOU Yuehong;LIAO Shangshang;RONG Sanqun;JIANG Yan;LIU Min;HU Wenxiao;CHANG Jiuzhou(Liuyang Hospital of Chinese Medicine,Liuyang Hunan China 410300)
出处
《中医学报》
CAS
2020年第3期647-651,共5页
Acta Chinese Medicine
基金
长沙市卫生计生委2017年度科研计划课题项目(18)。
关键词
“六郁同治法”
肥胖型糖尿病
脾瘅
湿热蕴脾证
胰岛素抵抗
糖代谢
脂代谢
炎症因子
瘦素
脂联素
"Liuyu Tongzhi method"
obesity type diabetes
Pi-dan
syndrome of dampness and heat accumulation in spleen
insulin resistance
glucose metabolism
lipid metabolism
inflammatory factors
leptin
adiponectin
