摘要
伤害性感受器可塑性变化是急性疼痛向慢性疼痛转变的关键。急性疼痛处置不当或损伤性因素持续性存在,会导致伤害性感受器持续性可塑性的改变,出现外周敏化和中枢敏化,表现为自发性疼痛、痛觉过敏和痛觉超敏。此时,轻微的刺激甚至是阈下刺激就能发生更强烈、更持久的痛觉过敏,该现象称为"痛觉过敏引发"。在慢性疼痛的产生和发展过程中,痛觉过敏引发的伤害性感受器可塑性改变发挥着重要的作用,是疼痛外周敏化的重要机制之一。
Nociceptor plasticity plays a critical role in the transition from acute to chronic pain.When acute pain is not properly handled or injury factors persist,it will lead to the continuous plasticity changes of nociceptor,peripheral sensitization and central sensitization,manifested as spontaneous pain,hyperalgesia and allodynia.Under this condition,mild stimulation or even subliminal stimulation can lead to more intense and lasting hyperalgesia,which is called"hyperalgesic triggering".The nociceptor plasticity change induced by hyperalgesia plays a key role in the generation and development of chronic pain,which is one of the important mechanisms of peripheral sensitization of pain.
作者
侯娜
张力
蒙臣
李清
胡扬根
HOU Na;ZHANG Li;MENG Chen;LI Qing;HU Yanggen(a.College of Pharmacy,Hubei University of Medicine,Shiyan 442000,China;Institute of Anesthesiology,Hubei University of Medicine,Shiyan 442000,China;Department of Anesthesiology,Taihe Hospital,Shiyan 442000,China;Department of Pain Clinic,Taihe Hospital,Shiyan 442000,China)
出处
《医学综述》
2020年第5期950-954,共5页
Medical Recapitulate
基金
十堰市科学技术研究与开发项目(17Y20)。
