摘要
目的评价单次亚麻醉剂量氯胺酮对结直肠肿瘤患者术后焦虑、抑郁等情绪反应的影响,便于为临床应用提供依据。方法根据纳入标准与排除标准选取我院2017年3月~2019年3月期间收治的60例结直肠癌患者。使用生理盐水的30例为对照组,使用单次亚麻醉剂量氯胺酮的30例为观察组,对比两组患者术前、术后焦虑和抑郁评分;麻醉时间、拔管时间、术后VAS评分以及不良反应。结果观察组术后焦虑、抑郁评分小于对照组,观察组麻醉时间、拔管以及术后24h的VAS评分均小于对照组,各项指标组间对比差异有统计学意义(P<0.05),观察组不良反应发生率小于对照组,差异有统计学意义(P<0.05)。结论单次亚麻醉剂量氯胺酮在结直肠肿瘤患者术后焦虑抑郁改善以及手术指标优化方面均有重要应用价值,临床可借鉴与推广应用。
Objective To evaluate the effect of single subanesthesia dose ketamine on postoperative anxiety,depression in patients with colorectal cancer.Methods 60 patients with colorectal cancer admitted to our hospital from March 2017 to March 2019 were selected.30 patients using normal saline as the control group,and 30 patients using single subanesthetic ketamine as the observation group.The preoperative and postoperative anxiety/depression,anesthesia time,extubation time,postoperative VAS score and adverse reactions.were compared between two groups.Results Postoperative anxiety and depression scores in the observation group were lower than those in the control group,and the anesthesia time,extubation and VAS scores 24 hours after surgery in the observation group were lower than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).Conclusion Single subanesthetic dose ketamine has important application value in the improvement of postoperative anxiety and depression as well as the optimization of surgical indicators in patients with colorectal cancer.
作者
王根生
卢锡华
杨清存
李廷坤
缪长虹
WANG Gensheng;LU Xihua;YANG Qingcun(Department of Anesthesiology,Cancer Hospital Affiliated to Zhengzhou University,Zhengzhou 450003,China)
出处
《国际精神病学杂志》
2020年第1期110-113,共4页
Journal Of International Psychiatry
基金
河南省医学科技攻关计划项目(编号:201404058).
关键词
氯胺酮
结直肠肿瘤
焦虑
抑郁
Ketamine
Colorectal neoplasms
Anxiety
Depression
