摘要
目的探讨单次亚麻醉剂量氯胺酮对结直肠肿瘤患者术后焦虑、抑郁等情绪反应的影响。方法选择62例行结直肠肿瘤清除术的患者,采用随机数字表法将其分为观察组和对照组各31例,观察组在手术前10 min单次给予亚麻醉剂量(0.3 mg·kg^(-1))氯胺酮,对照组给予等量生理盐水治疗,术后应用院内常规镇痛方案进行镇痛治疗,对比两组患者术后焦虑、抑郁等情绪反应情况。结果观察组术后48 h焦虑和抑郁评分低于对照组,组间比较差异有统计学意义(P<0.05);对照组术后48h时焦虑和抑郁评分高于治疗前,差异有统计学意义(P<0.05),观察组拔管后30 min疼痛视觉模拟评分法(VAS)评分低于对照组,两组比较差异有统计学意义(P<0.05)。结论对于行结直肠肿瘤手术的患者而言,在术前单次应用亚麻醉剂量的氯胺酮,可在一定程度上降低患者术后焦虑和抑郁等不良情绪的发生,值得临床推广应用。
Objective To explore effects of ketamine on anxiety and depression in patients with colorectal cancer after single dose of ketamine. Methods 62 cases of colorectal cancer patients were selected as study subjects,randomly divided into observation group and control group with each of 31 cases. The observation group was treated with 10 min before operation,and the patients were given a single dose of ketamine 0. 3 mg·kg^(-1). The control group was treated with the same amount of normal saline. Postoperative analgesia was used in the hospital,and anxiety,depression and other emotional reaction of the two groups patients were compared. Results The 48 h anxiety and depression scores of the observation group were lower than those of the control group,the difference was statistically significant( P < 0. 05). In the control group,the anxiety and depression scores of 48 h were higher than those before treatment,and there were significant differences( P < 0. 05). The 30 min VAS pain score after extubation in the observation group was lower than that in the control group,and there was significant difference between the two groups( P < 0. 05). Conclusions For patients with colorectal cancer surgery,a single dose of ketamine before surgery can certain reduce the incidence of anxiety and depression and other negative emotions,which worthy of clinical popularization and application.
出处
《安徽医药》
CAS
2017年第10期1888-1890,共3页
Anhui Medical and Pharmaceutical Journal
关键词
结直肠肿瘤
手术
氯胺酮
亚麻醉剂量
临床疗效
Colorectal neoplasms
Surgery
Ketamine
Dose of flax
Clinical efficacy
