摘要
目的观察丹参钩藤汤联合替米沙坦对伴有血压晨峰现象的非杓型高血压患者血压变异性、T淋巴细胞亚群和尿微量白蛋白/肌酐(ACR)的影响。方法将青海省妇幼保健院2017年2月—2018年11月治疗的128例伴有血压晨峰现象的非杓型高血压患者随机分为2组,对照组64例给予替米沙坦治疗,观察组64例在对照组治疗基础上给予丹参钩藤汤治疗,2组均治疗8周。记录2组治疗4周、8周后的晨峰血压、血压晨峰现象检出率、夜间收缩压下降率、非勺形血压检出率,观察2组治疗前后血压变异性、T淋巴细胞亚群、ACR的变化。结果观察组治疗4周、8周后的晨峰血压、血压晨峰现象检出率及ACR均显著低于对照组,夜间收缩压下降率显著高于对照组,而非勺形血压检出率显著低于对照组,差异均有统计学意义(P均<0.05)。2组治疗8周后的24 hSBP、24 hDBP、dSBP、dDBP、nSBP、nDBP、24 hSBPsd、24 hDBPsd、dSBPsd、dDBPsd、nSBPsd、nDBPsd均较治疗前显著降低,观察组治疗后以上指标均显著低于对照组,差异均有统计学意义(P均<0.05);2组治疗8周后CD3+、CD4+、CD8+、CD4+/CD8+比值均较治疗前显著改善,观察组改善情况显著优于对照组,差异均有统计学意义(P均<0.05)。结论丹参钩藤汤联合替米沙坦可显著抑制非杓型高血压患者血压晨峰现象,改善血压昼夜节律紊乱,抑制血压变异性,并促进机体细胞免疫功能恢复,减轻肾脏靶器官损害。
Objective It is to observe the effects of Danshen Gouteng decoction combined with telmisartan on blood pressure variability,T lymphocyte subsets and urine albumin-to-creatinine ratio(ACR)in patients with non-dipper hypertension and morning blood pressure surge.Methods 128 patients with non-dipper hypertension and morning blood pressure surge were randomly divided into two groups.64 patients in the control group were treated with telmisartan.64 patients in the observation group were treated with Danshen Gouteng Decoction.Both groups were treated for 8 weeks.The morning blood pressure surge,the detection rate of morning blood pressure surge,the decrease rate of nocturnal systolic blood pressure,and the detection rate of non-dipper blood pressure after 4 weeks and 8 weeks of treatment were recorded in the two groups.The changes of blood pressure variability,T lymphocyte subsets and ACR before and after treatment were observed in the two groups.Results The detection rate of morning peak blood surge,the detection rate of morning blood pressure surge and ACR after 4 weeks and 8 weeks of treatment in the observation group were significantly lower,and the decrease rate of nocturnal systolic blood pressure at night was significantly higher than that in the control group,the differences were statistically significant(P<0.05).After 8 weeks of treatment,24 h SBP,24 h DBP,dSBP,dDBP,nSBP,nDBP,24 h SBPsd,24 h DBPsd,dSBPsd,dDBPsd,nSBPsd,nDBPsd were significantly lower than those before treatment in the two groups,and the above indicators in the observation group were significantly lower than the control group,the differences were statistically significant(P<0.05);the CD3+,CD4+,CD8+,and CD4+/CD8+ratios in the two groups were significantly improved,and the improvement in the observation group was significantly better than that in the control group,the differences were statistically significant(P<0.05).Conclusion Danshen Gouteng decoction combined with telmisartan can significantly inhibit the morning peak of blood pressure,improve
作者
黄雨龙
黄子芳
杨鑫
HUANG Yulong;HUANG Zifang;YANG Xin(Qinghai Maternal and Child Health Hospital,Xining 810007,Qinghai,China;Changchun University of Traditional Chinese Medicine,Changchun 130117,Jilin,China;Xuzhou Medical University,Xuzhou 221004,Jiangsu,China)
出处
《现代中西医结合杂志》
CAS
2020年第6期610-614,共5页
Modern Journal of Integrated Traditional Chinese and Western Medicine
