摘要
目的观察冠心香丹片治疗急性心肌梗死冠脉介入术(PCI)后气虚血瘀证患者疗效及对心脏功能和血脂的影响。方法将2017年6月—2018年9月西安市中医医院收治的90例急性心肌梗死PCI术后气虚血瘀证患者随机分为治疗组和对照组。对照组45例给予常规西药治疗,治疗组45例在对照组治疗基础上给予冠心香丹片口服,2组均连续治疗2个月。统计2组症状疗效、心电图疗效,观察2组治疗前后血脂[三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]、血浆氨基末端脑钠肽前体(NT-proBNP)、心脏功能参数[左室舒张末期容积(LVEDV)、左室收缩末期容积(LVESV)、左室射血分数(LVEF)、二尖瓣下舒张早期血流峰值/舒张晚期血流峰值(E/A)]。结果治疗组症状及心电图总有效率分别为93.3%(42/45)、86.7%(39/45),对照组分别为80.0%(36/45)、66.7%(30/45),治疗组均明显高于对照组(P均<0.05)。治疗后2组TG、TC、LDL-C、NT-proBNP水平及LVEDV、LVESV均明显降低(P均<0.05),且治疗组均明显低于对照组(P均<0.05);2组HDL-C水平及LVEF、E/A均明显升高(P均<0.05),且治疗组HDL-C水平及LVEF均明显高于对照组(P均<0.05),2组间E/A比较差异无统计学意义(P>0.05)。结论冠心香丹片能明显改善急性心肌梗死PCI术后气虚血瘀证患者症状及心脏功能,且有调节血脂水平作用。
Objective It is to observe the curative effect of Guanxin Xiang Dan tablet on acute myocardial infarction with syndrome of Qi deficiency and blood stasis after PCI and its effect on cardiac function and blood lipid.Methods Ninety patients with acute myocardial infarction with syndrome of Qi deficiency and blood stasis after PCI treated in Xi’an Hospital of Traditional Chinese Medicine from June 2017 to September 2018 were randomly divided into a treatment group and a control group.45 patients in the control group were treated with conventional western medicine.45 patients in the treatment group were treated with Guanxin Xiang Dan tablets on the basis of treatment in the control group.Both groups were treated continuously for 2 months.The curative effect of symptoms and ECG in the two groups were evaluated.The indexes of blood lipids[triacylglycerol(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C)],plasma amino-terminal brain natriuretic peptide body(NT-proBNP),cardiac function parameters[left ventricular end-diastolic volume(LVEDV),left ventricular end-systolic volume(LVESV),left ventricular ejection fraction(LVEF),peak early blood flow in late mitral diastole/late diastole Peak blood flow(E/A)]before and after treatment were detected in the two groups.Results The total effective rate of symptom and ECG were 93.3%(42/45)and 86.7%(39/45)in the treatment group,and 80.0%(36/45)and 66.7%(30/45)in the control group,respectively.The rates in the treatment group were higher than those in the control group(P<0.05).After treatment,the levels of TG,TC,LDL-C,NT-proBNP,LVEDV,and LVESV were significantly reduced(P<0.05),and HDL-C level,LVEF,and E/A were significantly increased in the two groups(P<0.05),and the levels of TG,TC,LDL-C,NT-proBNP,LVEDV,and LVESV were significantly lower while that of HDL-C was higher in the treatment group than those in the control group(P<0.05).There was no significant difference in E/A between the two groups(P>0.05).Conclusion Gua
作者
刘兴林
郝伟
马振
唐秀林
胡乔斌
LIU Xinglin;HAO Wei;Ma Zhen;TANG Xiulin;HU Qiaobin(Shanxi University of Traditional Chinese Medicine,Xianyang 712046,Shaanxi,China;Xi’an Hospital of Traditional Chinese Medicine,Xi’an 710000,Shaanxi,China)
出处
《现代中西医结合杂志》
CAS
2020年第6期594-597,636,共5页
Modern Journal of Integrated Traditional Chinese and Western Medicine
基金
陕西省中医药管理局资助项目(LCPT054)
关键词
冠心香丹片
心肌梗死
PCI
血脂
心功能
Guanxin Xiang Dan tablet
myocardial infarction
PCI
blood lipid
cardiac function.
