摘要
目的探讨经皮冠状动脉介入术(PCI)联合重组人脑利钠肽(rhBNP)对急性心肌梗死(AMI)患者心肌酶谱及左心室功能的影响。方法将自2016年2月至2018年2月期间在宁波明州医院收治的AMI患者88例作为观察对象,通过随机抽签法分成观察组和对照组。所有患者均予以PCI治疗,其中对照组术前不进行其他处理,观察组术前则予以rhBNP静脉输注。分别对比两组患者治疗前后心肌酶谱指标、白细胞介素-37(IL-37)、左心室功能指标、心脏不良事件发生情况。结果治疗后观察组与对照组在肌酸激酶同工酶(CK-MB)、心肌肌钙蛋白I(cTnI)水平比较,前者更低;治疗后观察组与对照组IL-37水平比较,前者更高(均P<0.05)。治疗后观察组与对照组左心室射血分数(LVEF)水平比较,前者更高;治疗后观察组与对照组在左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)水平比较,前者更低(均P<0.05)。观察组与对照组在心脏不良事件发生率比较,前者更低(P<0.05)。结论PCI联合rhBNP应用于AMI患者中效果较佳,且有效改善患者的心肌酶谱以及左心室功能,降低心脏不良事件发生风险。
Objective To study the influence of percutaneous coronary intervention(PCI)combined with recombinant human brain natriuretic peptide(rhBNP)on myocardial enzyme and left ventricular function in patients with acute myocardial infarction(AMI).Methods 88 cases of AMI patients admitted to Ningbo Mingzhou Hospital from February 2016 to February 2018 were recorded,and all of them were divided into observation group and control group by random lottery method.All patients were treated with PCI.No other treatment was performed in the control group before surgery,rhBNP intravenous infusion was performed in the observation group before surgery.The indexes of myocardial enzymes interleukin-37(IL-37),left ventricular function before and after treatment and cardiac adverse events were compared between the two groups.Results After treatment,the levels of creatine kinase isoenzyme(CK-MB)and cardiactroponin I(cTnI)in the observation group were lower than in the control group,the IL-37 levelof the observation group was higher than the control group after treatment(all P<0.05).After treatment,the left ventricular ejection fraction(LVEF)level of the observation group was higher than the control group.After treatment,the left ventricular end diastolic diameter(LVEDD)and left ventricular end systolic diamete(LVESD)in the observation group were lower than the control group(all P<0.05).The incidence of adverse cardiac events was lower in the observation group than in the control group(P<0.05).Conclusion PCI combined with rhBNP is effective in AMI patients,and can effectively improve myocardial enzyme and left ventricular function,and reduce the risk of adverse cardiac events.
作者
余文杰
吴海宏
Yu Wenjie;Wu Haihong(Ningbo Mingzhou Hospital,Ningbo 315000,China)
出处
《心脑血管病防治》
2020年第1期89-91,95,共4页
CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT
关键词
急性心肌梗死
经皮冠状动脉介入术
重组人脑利钠肽
心肌酶谱
左心室功能
Acute myocardial infarction
Percutaneous coronary intervention
Recombinant human brain natriuretic peptide
Myocardial enzyme
Left ventricular function
