摘要
目的:分析原发性年轻(年龄≤40岁)宫颈腺癌患者的临床指标、病理学指标和预后差异,探讨原发性年轻宫颈腺癌患者预后的影响因素。方法:通过SEER数据库获取资料,比较年轻组(年龄≤40岁)和中老年组(年龄>40岁)的人口学信息、临床指标和病理指标,采用Kaplan-Meier法计算宫颈腺癌患者总生存率,采用Log-rank检验和COX回归分析宫颈腺癌患者生存的影响因素。结果:共纳入6 320例宫颈腺癌患者的资料进行分析,宫颈腺癌发病例数占所有宫颈癌患者的18.47%,而年轻组患者约占总宫颈腺癌患者的1/3。年轻组与中老年组宫颈腺癌患者的婚姻状态、种族、FIGO分期、肿瘤大小、分化程度、是否放疗方面差异有统计学意义(均P<0.001),而在病理类型间差异无统计学意义(P>0.05)。通过COX回归模型分析,年龄、婚姻状况、种族、疾病分期、肿瘤大小、分化程度和病理类型为影响宫颈腺癌预后的因素(均P<0.001)。采用Kaplan-meier法获得患者肿瘤特异性生存曲线,进行Log-rank法分析发现宫颈腺癌患者总生存时间为92.74个月,而年轻组和中老年组特异性生存时间分别为105.89个月和85.40个月。年轻组生存期显著长于中老年组(P<0.001)。年轻组和中老年组宫颈腺癌I期患者肿瘤特异性生存率分别为94.9%、89.2%,差异有统计学意义(P<0.01),而II期、III期、IV期之间肿瘤特异性生存率差异无统计学意义(P>0.05)。结论:年轻宫颈腺癌与中老年宫颈腺癌相比,恶性程度更低、分期较早、分化程度较高,预后较中老年宫颈腺癌好。但年轻宫颈腺癌发病率高,仍需要引起重视。
Objective: To analyze the clinical, pathological and prognostic parameters of young patients(≤40 years) with primary cervical adenocarcinoma, and explore the influencing factors of prognosis of young patients with with primary cervical adenocarcinoma. Methods: Data were obtained from SEER, a database. Population information, clinical indicators and pathological indexes of the young group(≤40 years) and the middle-aged group(>40 years) were compared. The Kaplan-Meier method was used to calculate the overall survival rate of patients with cervical adenocarcinoma. Log-rank test and Cox regression were used to analyze the influencing factors of survival in patients with cervical adenocarcinoma. Results: A total of 6,320 patients with cervical adenocarcinoma were included for analysis. Incidence of cervical adenocarcinoma accounted for 18.47% of all cervical cancer patients, while the young group accounted for 1/3 of the total cervical adenocarcinoma patients. There were significant differences between two groups in marital status, race, FIGO stage, tumor size, degree of differentiation and application of radiotherapy(P<0.001), but there was no significant difference in pathological types(P>0.05). COX regression model showed that age, marital status, race, stage of disease, tumor size, degree of differentiation and pathological type were the factors affecting the prognosis of cervical adenocarcinoma(P<0.001). Kaplan Meier method was used to obtain cancer-specific survival(CCS) curves. Log-rank analysis showed that the total survival time of cervical adenocarcinoma patients was 92.74 months, while the CCS in the young group and the middle-aged group were 105.89 months and 85.40 months, respectively. The survival time in the young group was significantly longer than that in the middle-aged group(P<0.001). The CCS rate of stage I patients in the young group and the middle-aged group were 94.9% and 89.2% respectively, the difference was statistically significant(P<0.01), but there were no significant differences betwe
作者
彭靓
曹保娣
杜雨璇
王晓晖
周景俭
Peng Liang;Cao Baodi;Du Yuxuan;Wang Xiaohui;Zhou Jingjian(Department of Gynecology,The Second People’s Hospital of Jingdezhen,Jingdezhen 333000,Jiangxi,China;Department of Endocrinology and Health Care,The Second People’s Hospital of Jingdezhen,Jingdezhen 333000,Jiangxi,China;Department of Gynecology and Obstetrics,First Affiliated Hospital of Gannan Medical University,Ganzhou 341000,Jiangxi,China)
出处
《肿瘤预防与治疗》
2020年第2期140-146,共7页
Journal of Cancer Control And Treatment
基金
景德镇市科技计划项目(编号:20181SFZC023)~~
关键词
宫颈腺癌
年轻
临床病理特征
预后分析
Cervical adenocarcinoma
Young patients
Clinicopathological features
Prognosis analysis
