摘要
中药复方可通过降低p38丝裂原活化蛋白激酶(MARK)磷酸化水平,抑制产生炎性因子,减缓腰椎间盘组织细胞凋亡,改善腰椎间盘组织功能。但中药复方介导p38MARK信号通路治疗腰椎间盘突出症也存在不足。因此,本文对中药复方介导p38MARK信号通路在腰椎间盘中的作用进行了简要综述。
Compound Chinese medicine can reduce the phosphorylation level of p38 mitogen-activated protein kinases(MARK), inhibit the production of inflammatory factors, down the apoptosis of lumbar intervertebral disc tissue slowly and improve the function of lumbar intervertebral disc tissue. However, there are some deficiencies in the treatment of lumbar disc herniation by p38 MARK signaling pathway mediated by compound Chinese medicine. Therefore, the effects of p38 mark signaling pathway mediated by compound Chinese medicine in lumbar intervertebral disc was reviewed in this paper.
作者
戴宇祥
姜宏
俞鹏飞
DAI Yu-xiang;JIANG Hong;YU Peng-fei(Department of Orthopedics,Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine,Suzhou 215009,Jiangsu Province,China)
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2020年第2期213-216,共4页
The Chinese Journal of Clinical Pharmacology
基金
国家自然科学基金资助项目(81473691)
江苏省卫计委青年医学重点人才课题基金资助项目(QNRC2016253)。
关键词
中药复方
腰椎间盘突出症
P38丝裂原活化蛋白激酶
重吸收
compound Chinese medicine
lumbar intervertebral disc
P38 mitogen-activated protein kinases
reabsorption
