摘要
目的:探讨利拉鲁肽对老年2型糖尿病合并高脂血症患者的内皮功能和免疫功能的影响。方法:选取我院2018年1月至2019年2月全科医学科门诊和住院收治的86例老年糖尿病合并高脂血症患者,随机分为对照组和利拉鲁肽组,各组43例,对照组采用二甲双胍治疗方法,利拉鲁肽组在此基础上进行皮下注射利拉鲁肽,两组患者连续观察2个月。分别在研究前后进行血糖和血脂的检测[血糖(FBG)、餐后2h血糖(2h PG)、糖化血红蛋白(HbA1c)、血脂总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)及体重指数(BMI)],比较内皮功能的指标(ET-1和NO)以及免疫功能[超敏C反应蛋白(hs-CRP),IgM和IgG]。结果:利拉鲁肽组治疗后较对照组治疗后FBG、2h PG、TC和TG降低(P<0.05);利拉鲁肽组治疗后与对照组治疗后HbA1c、LDL-C、HDL-C和BMI相比无统计学意义(P>0.05)。利拉鲁肽组治疗后ET-1较治疗前显著降低(P<0.01);利拉鲁肽组治疗后NO较治疗前无统计学意义(P>0.05);利拉鲁肽组治疗后ET-1水平较对照组治疗后降低(P<0.05),利拉鲁肽组治疗后NO水平较对照组升高(P<0.05)。利拉鲁肽组治疗后较对照组治疗后hs-CRP降低,而IgG较对照组升高(P<0.05)。结论:利拉鲁肽对老年2型糖尿病合并高脂血症降脂效果更明显,可以缓解内皮功能的损伤,增加免疫功能,降低炎症反应。
Objective:To investigate the effects of liraglutide on endothelial function and immune function in elderly patients with type 2 diabetes mellitus complicated with hyperlipidemia.Methods:86 elderly patients with diabetes mellitus complicated with hyperlipidemia were enrolled in the general practice department of the hospital from January 2018 to February 2019.They were randomly divided into the control group and the liraglutide group,with 43 cases in each group.The control group was treated with metformin treatment.The liraglutide group was given subcutaneous injection of liraglutide.The two groups were observed for 2 months.Blood glucose and blood lipids were measured before and after the study[blood sugar(FBG),postprandial 2 h blood glucose(2 h PG),glycosylated hemoglobin(HbA1c),total cholesterol(TC),triglyceride(TG),low density lipid)Protein(LDL-C),high-density lipoprotein(HDL-C)and body mass index(BMI),comparing endothelial function indicators[ET-1 and NO]and immune function[hypersensitive C-reactive protein(hs-CRP),IgM and IgG].Results:After treatment with liraglutide group,FBG,2 h PG,TC and TG were lower than those in the control group(P<0.05).After treatment with liraglutide group,HbA1c,LDL-C and HDL-C were compared with the control group.There was no significant difference between BMI and BMI(P>0.05).After treatment with liraglutide,ET-1 was significantly lower than that before treatment(P<0.01).There was no significant difference in NO after treatment with liraglutide group(P>0.05).After treatment with liraglutide group,ET The level of-1 was lower than that of the control group(P<0.05),and the level of NO was higher in the liraglutide group than in the control group(P<0.05).The hs-CRP was decreased after treatment with the liraglutide group compared with the control group,while the IgG was higher than the control group(P<0.05).Conclusion:The effect of lilalutide on the elderly type 2 diabetes mellitus with hyperlipidemia is more obvious.It can alleviate the damage of endothelial function,increase the immu
作者
常盼
张晓萌
王西辉
李静
吴娟
于军
CHANG Pan;ZHANG Xiaomeng;WANG Xihui(The Second Affiliated Hospital of Xi'an Medical University, Shaanxi Xi'an 710038, China)
出处
《河北医学》
CAS
2020年第3期433-437,共5页
Hebei Medicine
基金
国家自然科学基金，(编号:81870172)
陕西省科技厅项目，(编号:2018SF-129,2018SF-114)
西安医学院第二附属医院院级课题，(编号:18KY0111)
关键词
2型糖尿病
利拉鲁肽
高脂血症
内皮功能
免疫功能
Type 2 diabetes mellitus
liraglutide
Hyperlipemia
Endothelial function
Immune function
