摘要
目的:探讨肺表面活性物质(PS)联合无创正压通气对新生儿呼吸窘迫的疗效观察及对血气指标的影响。方法:选择2017年2月至2019年2月我院接诊的100例新生儿呼吸窘迫患者进行研究,通过随机数表法分为观察组(n=52)和对照组(n=48),对照组使用无创正压通气治疗,观察组在此基础上联合PS治疗,比较两组临床疗效、氢离子浓度指数(pH)、二氧化碳分压(PCO2)、氧合指数(PaO2/FiO2)水平、通气时间、住院时间、住院费用及并发症发生情况。结果:治疗后,观察组临床疗效总有效率90.38%高于对照组的70.83%(P<0.05);治疗后,两组患儿血气指标水平较治疗前均显著改善(P<0.05),且观察组pH、PaO2/FiO2水平均于对照组,PCO2水平低于对照组(P<0.05);观察组患儿通气时间、住院时间、住院费用明显低于对照组,(P<0.05);两组患者不良反应总发生率分别为19.23%、43.75%,差异显著(P<0.05)。结论:PS联合无创正压通气治疗新生儿呼吸窘迫效果显著,可有效改善患儿血气指标,值得推广与运用。
Objective:To study the effect of Lung surface active substances(PS)combined with noninvasive positive pressure ventilationin treatment of Neonatal respiratory distressand its effectson blood gas index.Methods:100 newborn patients with respiratory distress admitted to our hospital from February 2017 to February 2019 were selected for the study,by stochastic indicator method,divided into the observation group(n=52)and control group(n=48)and control group using noninvasive positive pressure ventilation therapy,observation group on the basis of this combined therapy with PS,comparing two groups of clinical curative effect,the hydrogen ion concentration index(pH),CO2 partial pressure(PCO2),oxygenation index(PaO2/FiO2)level,the aeration time level of complications,length of hospital stay,hospital expenses.Results:After treatment,the total effective rate of the observation group was 90.38%higher than that of the control group(P<0.05).Before treatment,there was no significant difference in blood gas index between the two groups(P>0.05).After treatment,blood gas index levels of children in both groups were significantly improved compared with those before treatment(P<0.05).PH,PaO2/FiO2 levels of children in the observation group were significantly higher than those in the control group,and PCO2 levels were significantly lower than those in the control group(P<0.05).Ventilation time,length of stay and cost of hospitalization in the observation group were significantly lower than those in the control group(P<0.05).The total incidence of adverse reactions in the two groups was 19.23%and 43.75%,respectively,with significant differences(P<0.05).Conclusion:PS combined with non-invasive positive pressure ventilation has a significant effect in the treatment of neonatal respiratory distress,which can effectively improve the blood gas index of children,and is worthy of promotion and application.
作者
陈少军
陈全景
周凤霞
CHEN Shaojun;CHEN Quanjing;ZHOU Fengxia(Dongfeng Hospital Affiliated to Hubei Medical College,Hubei Shiyan 442008,China)
出处
《河北医学》
CAS
2020年第3期411-415,共5页
Hebei Medicine
基金
湖北省自然科学基金项目，(编号:2017YFM179823)
关键词
新生儿
呼吸窘迫
肺表面活性物质
无创正压通气
血气指标
The newborn
Respiratory distress
Lung surface active substances
Noninvasive positive pressure ventilation
Blood gas index
