摘要
目的评价小儿肝移植术后远期认知功能的转归及年龄因素在其中的作用。方法肝移植术后满1年小儿95例,测试时年龄2岁6个月~6岁11个月,通过韦氏幼儿智力量表评价患儿认知功能。根据移植手术时年龄分为2组:≤1岁组(L1组,n=65)和>1岁组(M1组,n=22)。结果与正常值比较,肝移植术后1年患儿言语理解及总智商评分降低,智商中等以上比例减少,L1组患儿言语理解评分降低,智商中等以上比例减少,M1组患儿言语理解、视觉空间及总智商评分降低,智商中等以上比例减少,中等以下比例升高(P<0.05);与L1组比较,M1组患儿总智商评分降低,智商中等以上比例减少,中等以下比例升高(P<0.05)。结论小儿肝移植术后远期认知功能低于正常儿童,肝移植术时≤1岁患儿远期认知功能优于>1岁患儿。
Objective To evaluate the outcome of long-term cognitive function after liver transplantation in children and the role of age factor.Methods Ninety-five pediatric patients,aged 2 yr and 6 months to 6 yr and 11 months at test,at least 1 yr after liver transplantation,were selected.The children′s cognitive function was assessed using Chinese Wechsler Intelligence Scale for Children.The patients were divided into 2 groups according to the age at transplantation:≤1 yr group(L1 group,n=65)and>1 yr group(M1 group,n=22).Results Compared with the normal value,the scores of verbal comprehension and total intelligence quotient(IQ)were significantly decreased,and the proportion of children who had above-average IQ was decreased 1 yr after liver transplantation,the scores of verbal comprehension were decreased,and the proportion of children who had above-average IQ was decreased in group L1,and the scores of verbal comprehension,visual space and total IQ were significantly decreased,the proportion of children who had above-average IQ was reduced,and the proportion of children who had below-average IQ was increased in group M1(P<0.05).Compared with L1 group,the total IQ score was significantly decreased,the proportion of children who had above-average IQ was reduced,and the proportion of children who had below-average IQ was increased in group M1(P<0.05).Conclusion The long-term cognitive function of children after liver transplantation is lower than that of normal children,and the long-term cognitive function of children≤1 yr is better than that of children>1 yr.
作者
朱辉
蒋旭亮
黄莉莉
张骁
田为天
苏殿三
俞卫锋
Zhu Hui;Jiang Xuliang;Huang Lili;Zhang Xiao;Tian Weitian;Su Diansan;Yu Weifeng(School of Medicine,Soochow University,Suzhou 215123,China;Department of Anesthesiology,Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200127,China;Department of Anesthesiology,Estern Hepatobiliary Surgery Hospital,Shanghai 200438,China)
出处
《中华麻醉学杂志》
CAS
CSCD
北大核心
2019年第10期1165-1167,共3页
Chinese Journal of Anesthesiology
关键词
肝移植
认知
儿童
年龄因素
Liver transplantation
Cognition
Child
Age factors
