摘要
目的:探讨参麦注射液结合早期肠内营养支持(EEN)对慢性充血性心力衰竭(CCHF)急性加重期患者心功能、体能状况及生存质量的影响。方法:选取因CCHF急性加重住院患者60例,按随机数字表法分为观察组与对照组,每组30例。两组均作基础治疗,对照组予以EEN治疗;观察组予以参麦注射液联合EEN治疗。比较两组临床疗效,治疗前后评价6 min步行试验(6MWT)、计时起立-行走试验(TUGT)、10米最大步行速度(MWS)、维持自理整合劳务研究项目问卷--7项问卷(PRISMA-7)、简易虚弱问卷(FRAIL)、Fried衰弱量表、简易体能状况量表(SPPB)、心力衰竭生存质量问卷(MLHF-Q),心脏彩超检测左室射血分数(LVEF)、左心室舒张末期内径(LVEDD)和左心室收缩末期内径(LVESD),测定血清脑利钠肽(BNP)水平。结果:观察组总有效率96.67%,显著高于对照组的76.67%(P<0.05)。治疗后,观察组的LVEF及6MWT显著高于对照组,血清BNP水平均显著低于对照组(P<0.05),但组间治疗前后LVEDD、LVESD比较,差异无统计学意义(P>0.05)。治疗后,观察组的TUGT及PRISMA-7、FRAIL、Fried、MLHF-Q评分均显著低于对照组,MWS及SPPB评分显著高于对照组(P<0.05)。观察组不良反应率为10.00%,对照组为20.00%,两组比较差异无统计学意义(P>0.05)。结论:参麦注射液结合EEN能够改善CCHF急性加重患者的心功能,提高体能水平并改善生存质量。
Objective: To investigate the effects of Shenmai injections combined with early enteral nutrition(EEN) on heart function, physical condition and quality of life in patients with acute exacerbation of chronic congestive heart failure(CCHF). Methods: Sixty patients with acute exacerbations of CCHF were randomly divided into observation and control groups, with 30 cases in each group. On the base of conventional treatment, patients in the control group were treated with EEN, patients in the observation group were treated with Shenmai injections and EEN. The clinical efficacies of the two treatments were compared. Before and after the treatments, the scores of 6-Minute Walk Test(6 MWT), timed "Up & Go"test(TUGT), 10 m maximum walking speed(MWS), program of research on integration of services for the maintenance of autonomy-7(PRISMA-7), Simple Frailty Questionnaire(FRAIL), Fried Weakness Scale,Short Physical Performance Battery(SPPB) and Minnesota Living with Heart Failure Questionnaire(MLHFQ) were recorded;left ventricular ejection fractions(LVEF), left ventricular end diastolic diameters(LVEDD)and left ventricular end systolic diameters(LVESD) were detected by heart color ultrasound;and serum levels of brain natriuretic peptide(BNP) were determined. Results: The total effective rate of the observation group was significantly higher than that of the control group(96.67% vs. 76.67%, P <0.05).After treatment, the LVEF and 6 MWT in the observation group were significantly higher than those in the control group, the serum BNP levels were significantly lower than those of the control group(P<0.05), while there were no significant differences in LVEDD and LVESD between the two groups before and after treatment(P>0.05). After treatment, the scores of TUGT, PRISMA-7, FRAIL, Fried and MLHF-Q in the observation group were significantly lower than those of the control group, while the scores of MWS and SPPB were significantly higher(P <0.05). There was no significant difference of adverse reaction rate between the observation g
作者
张一炎
殷丽萍
张苏洁
谷明林
许小进
沈竹阳
ZHANG Yiyan;YIN Liping;ZHANG Sujie;GU Minglin;XU Xiaojin;SHEN Zhuyang(Jiangsu Province Academy of Traditional Chinese Medicine,Nanjing 210028,China)
出处
《药学与临床研究》
2020年第1期10-14,共5页
Pharmaceutical and Clinical Research
基金
2017年度江苏省中医药局科技项目(JD201713)
关键词
慢性充血性心力衰竭
参麦注射液
肠内营养
心功能
体能状况
生存质量
Chronic congestive heart failure
Shenmai injection
Enteral nutrition
Heart function
Physical condition
Quality of life
