摘要
目的在治疗中重度癌痛过程中,对硫酸吗啡缓释片与芬太尼透皮贴剂疗效进行评价。方法回顾性分析2018年1月至2019年6月诊治的58例癌痛患者的处方及临床资料,依据其用药和治疗方法的不同分为甲组和乙组,每组29例。甲组用硫酸吗啡缓释片,乙组用芬太尼透皮贴剂,对比2组的疼痛缓解程度、不良反应发生率及生活质量改善情况。结果止痛药用药7 d后,2组疼痛中度(Ⅱ和Ⅲ)2组间差异无统计学意义(P>0.05);止痛药用药14 d后,2组患者完全缓解和明显缓解差异无统计学意义(P>0.05)。用药7 d后,甲组患者的便秘、恶心、呕吐及尿潴留的发生时间较乙组早,发生率较乙组高,差异有统计学意义(P<0.05)。用药14 d后,乙组较甲组应用止吐剂、缓泻剂更少,差异有统计学意义(P<0.05),但止痛效果未受影响。2组治疗7 d生活质量有明显提高,治疗14 d后生活质量改善显著,其中甲组生活质量良好、较好分别由治疗前的10.3%提高到治疗后的48.3%,有显著提升(P<0.05),乙组生活质量良好、较好由治疗前的3.4%提高到治疗后的58.6%(P<0.05)。结论芬太尼透皮贴剂与同类的第三阶梯阿片类口服药物相比较止痛效果相似,但不良反应发生率更低、应用方便。
Objective To investigate the efficacy of morphine sulfate sustained release tablets and fentanyl transdermal patch in treatment of moderate and severe cancerous pain.Methods The clinical data about 58 patients with cancerous pain who were treated in our hospital from January 2018 to June 2019 were retrospectively analyzed.According to different medications and treatment methods,these patients were divided into group A and group B,and the patients in group A and group B were treated by morphine sulfate sustained release tablets and fentanyl transdermal patches,respectively.The pain remission degree,incidence of adverse reactions and life quality of patients were observed and compared between the two groups.Results After 7-day and 14-day medication,there were no significant differences in the cases with pain remission degreeⅡbetween the two groups(P>0.05),but the incidence rate of adverse reactions in group A was significantly higher than that in group B(P<0.05).After 2-week medication,the life quality of patients in group A was superior to that in group B(P<0.05).Conclusion The fentanyl transdermal patch has similar analgesia effects,as compared with those by the third stage opioid oral drugs in treatment of cancerous pain,but the incidence of adverse reactions in former is lower,and the application is more convenient.
作者
周秀丽
ZHOU Xiuli(Department of Pharmacy, Ningjin Hospital for Maternal and Child Health,Hebei,Ningjin 055550,China)
出处
《河北医药》
CAS
2020年第1期120-122,128,共4页
Hebei Medical Journal
关键词
硫酸吗啡缓释片
芬太尼透皮贴剂
癌痛
morphine sulfate sustained release tablets
fentanyl transdermal patch
pain due to cancer
