摘要
目的:观察右美托咪定联合丙泊酚在老年患者无痛胃镜中的临床效果.方法:选择笔者所在医院2018年5月-2019年4月进行无痛胃镜的老年患者100例,将其随机分为对照组和观察组,每组50例.观察组患者首先静脉注射0.4μg/kg右美托咪定,等待10 min后静脉注射1.5 mg/kg丙泊酚.对照组患者先静脉注射与右美托咪定同等容量的0.9%氯化钠注射液,等待10 min后静脉注射1.5 mg/kg丙泊酚.比较两组患者麻醉诱导时间、苏醒时间、定向力恢复时间和不良反应发生情况.结果:观察组患者麻醉诱导时间(2.35±0.25)min,明显短于对照组的(3.73±0.41)min,差异有统计学意义(P<0.05).观察组苏醒时间(5.65±0.72)min,定向力恢复时间(7.86±1.04)min,均明显早于对照组的(7.43±1.11)、(9.73±1.23)min,差异有统计学意义(P<0.05).观察组心动过缓发生率略高于对照组,但两组比较差异无统计学意义(P>0.05);观察组低血压、短暂呼吸抑制发生率均明显低于对照组,差异有统计学意义(P<0.05).观察组不良反应发生率为16.0%,明显低于对照组的38.0%,差异有统计学意义(P<0.05).结论:右美托咪定联合丙泊酚用于老年患者无痛胃镜检查中,能明显提高麻醉效果,降低不良反应发生率.
Objective:To observe the clinical effect of Dexmedetomidine combined with Propofol on painless gastroscopy in elderly patients.Method:A total of 100 elderly patients with painless gastroscopy in our hospital from May 2018 to April 2019 were selected and randomly divided into the control group and the observation group,50 cases in each group.Patients in the observation group were first intravenously injected with 0.4μg/kg Dexmedetomidine,and then intravenously injected with 1.5 mg/kg Propofol after waiting for 10 min.Patients in the control group were first intravenously injected with 0.9%Sodium Chloride Injection of the same volume as Dexmedetomidine,and then intravenously injected with 1.5 mg/kg Propofol after waiting for 10 min.The anaesthesia induction time,waking time,directional force recovery time and adverse reaction of the two groups were compared.Result:The anesthesia induction time in the observation group was(2.35±0.25)min,significantly shorter than(3.73±0.41)min in the control group,the difference was statistically significant(P<0.05).The waking time(5.65±0.72)min and the recovery time of directional force(7.86±1.04)min in the observation group were significantly earlier than(7.43±1.11)and(9.73±1.23)min in the control group,the differences were statistically significant(P<0.05).The incidence of bradycardia in the observation group was slightly higher than that in the control group,but the difference between the two groups was not statistically significant(P>0.05).The incidence of hypotension and transient respiratory suppression in the observation group were significantly lower than those in the control group,the differences were statistically significant(P<0.05).The incidence of adverse reaction in the observation group was 16.0%,which was significantly lower than 38.0%in the control group,the difference was statistically significant(P<0.05).Conclusion:Dexmedetomidine combined with Propofol in painless gastroscopy of elderly patients can significantly improve the anesthesia effect,reduce the i
作者
程章仁
姜闽英
魏海翔
罗年丰
李丹
CHENG Zhangren;JIANG Minying;WEI Haixiang;LUO Nianfeng;LI Dan(Nanping First Hospital Affiliated to Fujian Medical University,Nanping 353000,China)
出处
《中外医学研究》
2020年第2期43-45,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
右美托咪定
丙泊酚
无痛胃镜
不良反应
Dexmedetomidine
Propofol
Painless gastroscope
Adverse reaction
