摘要
目的探讨足月儿与早产儿败血症病原茵、细胞因子及免疫功能差异。方法选取2017年1月-2019年2月在江苏省盐城市滨海县人民医院治疗的新生儿败血症患者192例,其中早产儿118例,足月儿74例,采用卡方检验和t检验比较两组病原菌、细胞因子及免疫功能差异。结果早产儿革兰阴性菌比例为25.42%,明显高于足月儿(P<0.05),而革兰阳性茵比例为71.19%,明显低于足月儿(P<0.05);早产儿降钙素原(PCT)为(1.89±0.94)ng/mL,明显低于足月儿(P<0.05),而肿瘤坏死因子-α(TNF-α)为(98.28±21.18)pg/mL,明显高于足月儿(P<0.05);早产儿免疫球蛋白G(lgG)和免疫球蛋白M(lgM)分别为(5.10±1.12)g/L和(0.17±0.08)g/L,明显低于足月儿(P<0.05)。结论足月儿与早产凡败血症病原茵、细胞因子及免疫功能有明显差异,值得进一步研究。
Objective To explore the difference of pathogenic bacteria,cytokines and immune function between fullterm and premature infants with sepsis.Methods 192 cases of neonatal sepsis treated in Xuzhou Medical University from January 2017 to February 2019 were selected,including 118 premature infants and 74 full-term infants,Chisquare test and 1-test were used to compare the difference of pathogenic bacteria,cytokines and immune function between the two groups.Results The proportion of Gram-negative bacteria in the blood samples of the premature infants was 25.42%,significantly higher than that of the full-term infants(P<0.05),while the proportion of Gram-positive bacteria in the blood samples of the premature infants was 71.19%,significantly lower than that in full-term infants(P<0.05).The PCT level of the preterm infants was(1.89±0.94)ng/mL,significantly lower than that of the full-term infants(P<0.05),while the TNF-a level of the premature infants was(98.28+21.18)pg/mL,significantly higher than that of the full-term infants(P<0.05).The levels of lgC and IgM of the preterm infants were(5.10±1.12)g/L and(0.17±0.08)g/L,both significantly lower than those of the fullterm infants(both P<0.05).Conclusion There are significant differences in pathogenic bacteria,cytokines and immune function between full-term and.premature infants with sepsis,which deserves further study.
作者
杨婷婷
王军
YANG Tinging;WANG Jun(Clinical Laboratory,Hospital affliated to Xuzhou Medical University,Xuzhou 224500,China)
出处
《中国急救复苏与灾害医学杂志》
2020年第2期201-203,211,共4页
China Journal of Emergency Resuscitation and Disaster Medicine
关键词
足月儿
早产儿
败血症
病原菌
细胞因子
免疫功能
Full-term infants
Premalure infants
Septicemia
Pathogens
Cylokines
Immune function
