摘要
目的探讨钆塞酸二钠(Gd-EOB-DTPA)增强T1mapping成像对肝纤维化分期的评估价值。方法本研究纳入健康志愿者23名(S0组),慢性乙型肝炎肝纤维化S1期13例,S2期13例,S3期26例,S4期24例。检查采用Look-Locker序列于Gd-EOB-DTPA增强前及增强后20 min(肝胆期)采集T1mapping图像,并测量肝组织T1弛豫时间,同时计算肝胆期T1弛豫时间减低率(ΔT1)。采用单因素方差分析比较增强前及增强后20 min不同组别之间肝脏ΔT1及T1弛豫时间,并使用受试者工作特征曲线(ROC)分析肝脏ΔT1及T1弛豫时间对相邻肝纤维化级别的诊断效能。结果 S0组肝增强前T1弛豫时间(T1 pre)、肝胆期T1弛豫时间(T1HBP)、ΔT1分别为(777.70±72.40) ms、(230.09±37.73) ms、(70.06±6.61)%,S1组为(860.69±90.14) ms、(310.62±104.49) ms、(64.42±13.80)%,S2组分别为(903.15±80.01) ms、(316.38±115.41) ms、(63.44±13.56)%,S3组分别为(822.92±104.59) ms、(554.54±86.7) ms、(39.18±11.57)%,S4组分别为(924.16±99.98) ms、(558.69±101.00) ms、(38.93±12.41)%。S0、S1、S2、S3与S4组T1pre及T1HBP差异均有统计学意义(P<0.05);T1pre、T1HBP、ΔT1鉴别S0与S1的AUC分别为0.771、0.771、0.629,鉴别S2与S3的AUC分别为0.582、0.933、0.913。结论 Gd-EOB-DTPA增强T1mapping成像对肝纤维化的评估有一定的价值。
Objective To evaluate the value of Gd-EOB-DTPA enhanced T1 mapping imaging in the evaluation of liver fibrosis staging. Methods A total of 99 patients were included in the study. There were 23 healthy volunteers(S0) in the control group,13 in the S1 phase of chronic hepatitis B,15 in the S2 phase,26 in the S3 phase,and 24 in the S4 phase. T1 mapping images were collected using the Look-Locker sequence before Gd-EOB-DTPA enhancement and 20 minutes after enhancement(hepatobiliary phase),and the T1 relaxation time of liver tissue was measured,and the T1 relaxation time reduction rate of hepatobiliary phase was calculated. One-way analysis of variance was used to compare the T1 relaxation time reduction rate and T1 relaxation time between different groups before and after enhancement,and the ROC curve was used to analyze the T1 relaxation time reduction rate and T1 relaxation time of the liver. Diagnostic efficacy of adjacent liver fibrosis levels was determined. Results The T1 pre,T1 HBP and ΔT1 of the S0 group were(777.70±72.40) ms,(230.09±37.73) ms,(70.06±6.61) %,and the S1 group was(860.69±90.14) ms,(310.62±104.49) ms.( 64.42±13.80) %,S2 group is( 903.15±80.01) ms,( 316.38±115.41) ms,( 63.44±13.56) %,and S3 group is( 822.92±104.59) ms,( 554.54±86.7) ms,( 39.18±11.57) %,S4 group were( 924.16±99.98) ms,( 558.69±101.00) ms,( 38.93±12.41) %. There were significant differences in T1 pre and T1 HBP between S0,S1,S2,S3 and S4 groups(P< 0.05). T1 pre,T1 HBP,ΔT1 identified AUC of S0 and S1 were 0.771,0.771,0.629,respectively. The AUC is 0.582,0.933,and 0.913,respectively. Conclusion Gd-EOB-DTPA enhanced T1 mapping imaging has certain value in the evaluation of liver fibrosis.
作者
张涛
陆健
张学琴
张继云
ZHANG Tao;LU Jian;ZHANG Xueqin(Department of Radiology,the Third Hospital Affiliated of Nantong University,Nantong,Jiangsu Province 226006,P.R.China)
出处
《临床放射学杂志》
CSCD
北大核心
2019年第11期2096-2099,共4页
Journal of Clinical Radiology
基金
南通市科技计划基金资助项目(编号:MS22015073)
