摘要
目的通过对我院主要病原菌的分布及耐药性情况进行分析,为临床合理使用抗菌药物提供参考。方法回顾性分析2017年9月~2019年4月我院主要病原菌的分布情况,并对革兰阴性菌和革兰阳性菌进行耐药性分析。结果临床分离的1936株病原菌中,铜绿假单胞菌、大肠埃希菌、肺炎克雷伯菌、金黄色葡萄球菌、鲍曼不动杆菌、嗜麦芽寡养单胞菌、白色念珠菌、阴沟肠杆菌、屎肠球菌、粪肠球菌10种细菌是我院主要的病原菌,占检出菌的74.69%。铜绿假单胞菌对阿米卡星的耐药性最低,阴沟肠杆菌对大部分抗菌药物的耐药性<30.00%,鲍曼不动杆菌以及嗜麦芽寡养单胞菌对大部分抗菌药物的耐药性>50.00%,肺炎克雷伯菌对大部分抗菌药物的耐药性>30.00%,大肠埃希菌对不同抗菌药物的耐药性不同,金黄色葡萄球菌对红霉素、阿奇霉素、克林霉素的耐药性>50.00%,屎肠杆菌以及粪肠杆菌对头孢唑林以及克林霉素的耐药性均为100.00%。耐碳青酶烯类抗菌药物的鲍曼不动杆菌、铜绿假单胞菌、肠杆菌科细菌检出率分别为64.80%、29.07%、15.09%;耐甲氧西林类抗菌药物的金黄色葡萄球菌检出率为32.45%。结论医院应定期进行病原菌耐药性分析,加强对抗菌药物使用的监督和管理,以减少多重耐药菌产生。
Objective To analyze the distribution and drug resistance of main pathogenic bacteria in our hospital and provide guidance of rational use of antimicrobial agents for clinic.Methods The distribution of major pathogens in our hospital from September 2017 to April 2019 was analyzed retrospectively,and drug resistance of major gram-negative bacteria and gram-positive bacteria was analyzed.Results Among the 1936 strains of pathogenic bacteria isolated clinically,pseudomonas aeruginosa,escherichia coli,klebsiella pneumoniae,staphylococcus aureus,acinetobacter baumannii,stenotrophomonas maltophilia,candida albicans,enterobacter cloacae,enterococcus excreta and enterococcus faecalis were the main pathogenic bacteria in our hospital,accounting for 74.69%of the bacteria detected.The resistance of pseudomonas aeruginosa to amikacin was the lowest,the enterobacter cloacae to most antibacterial drugs was less than 30.00%,the resistance of acinetobacter baumannii and oligomonas maltophilia to most antibacterial drugs was more than 30.00%,the resistance of klebsiella pneumoniae the resistance of Escherichia coli to different antibacterial drugs was was different,the resistance of staphylococcus aureus to erythromycin,azithromycin and clindamycin was more than 50.00%,the resistance of enterobacter faecium and enterobacter faecalis to cefazolin and clindamycin was 100.00%;The detection rates of acinetobacter baumannii,pseudomonas aeruginosa and enterobacteriaceae in carbapenem resistant antibacterial drugs were 64.80%,29.07%and 15.09%respectively,the detection rate of staphylococcus aureus in methoxycillin resistant antibacterial drugs was 32.45%.Conclusion The hospital should analyze the distribution and drug resistance of main pathogenic bacteria regularly,and strengthen the supervision and management of the use of antibacterial drugs to reduce the generation of multiple drug-resistant bacteria.
作者
罗坤
熊耀翼
李辉霞
邹倩
刘竞颖
杨朋
王春艳
LUO Kun;XIONG Yao-yi;LI Hui-xia;ZOU Qian;LIU Jing-ying;YANG Peng;WANG Chun-yan(Department of laboratory,Sichuan Provincial Fourth People's Hospital,Chengdu 610016,China)
出处
《医学信息》
2020年第2期97-100,共4页
Journal of Medical Information
关键词
病原菌
临床分布
耐药性
Pathogenic bacteria
Clinical distribution
Drug resistance
