摘要
目的探讨负压封闭引流术(VSD)对剖宫产术后产妇预后及炎症反应的影响。方法选取2016年2月-2019年4月在某院行剖宫产术后存在切口愈合不良的患者84例,随机分为对照组和观察组,每组42例。对照组采用常规多孔引流,观察组采用VSD治疗,比较两组患者表皮细胞生长因子(EGF)、碱性成纤维生长因子(bFGF)、血清白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平以及切口治疗情况。结果两组的EGF和bFGF水平在术后7d时明显上升,IL-6和TNF-α则在术后1d时升高,而在术后7d则明显降低,且观察组变化更显著(P<0.01)。观察组切口面积愈合率明显高于对照组,切口愈合时间和换药次数低于对照组,差异有统计学意义(P<0.01)。结论VSD能调节EGF、bFGF等因子的表达,促进剖宫产术后切口肉芽组织生长,同时能通过减少炎症反应的发生,促进切口的愈合。
Objective To investigate the effect of vacuum sealing drainage on prognosis and inflammatory response of parturients after cesarean section.Methods A total of 84 patients with poor wound healing after cesarean section in a hospital from February 2016 to April 2019 were randomly divided into the Observation Group and the Control Group,42 cases in each group.The Control Group was treated with conventional porous drainage while the Observation Group was treated with vacuum sealing drainage.After the treatment,the two groups were compared in terms of EGF,bFGF,IL-6 and TNF-1 levels as well as the treatment of the incision.Results Both groups had the EGF and bFGF levels significantly increased at 7 d after the operation and had the IL-6 and TNF-α levels increased at 1d after the operation but significantly decreased at 7 d after the operation,and the Observation Group had more significant change(P<0.01).The healing rate of incision in the Observation Group was significantly higher than that in the Control Group while the wound healing time and times for dressing change in the Observation Group were lower than those in the Control Group(P<0.01).Conclusion VSD can regulate the expression of EGF,bFGF and other factors,promote the growth of granulation tissue after cesarean section,and promote the healing of incision by reducing the occurrence of inflammatory response.
作者
李海玲
陆月婷
林颖
LI Hai-ling;LU Yue-ting;LIN Ying(The Second Affiliated Hospital of Guangdong Medical University,Zhanjiang 524007,China)
出处
《广东医科大学学报》
2020年第1期81-83,共3页
Journal of Guangdong Medical University
基金
湛江市科技计划项目(No.180905093334342)
关键词
负压封闭引流术
剖宫产
预后
炎症反应
影响
vacuum sealing drainage
cesarean section
inflammatory reaction
impact
