摘要
如何将生物活性分子高效投递到靶标的细胞和组织仍然是生物治疗领域研究人员面临的难题之一。直到细胞穿膜肽(cell penetrating peptides,CPPs)的出现,其可介导多种外源性功能分子(核酸、多肽、蛋白质和化学药物)进入细胞,而且不影响外源活性分子的功能发挥。另外,CPPs在传递外源活性成分进入肿瘤组织和细胞方面表现出更具应用前景的优势。因此,通过对CPPs的分类、鉴定方法、穿膜机制、其在抗肿瘤治疗中的最新应用以及尚需要解决的问题进行综述,以期为新型CPPs的鉴定和其抗肿瘤治疗策略提供参考。
How to deliver bioactive molecules efficiently to target cells and tissues is still one of the challenges for researchers in the field of bioremediation. Until the advent of CPPs,its can mediate a variety of exogenous functional molecules( nucleic acids,polypeptides,proteins,and chemical drugs) into the cell without affecting the function of exogenous active molecules. In addition,CPPs show a more promising advantage in transferring exogenous active ingredients into tumor tissues and cells. Therefore,the classification,identification method,penetrating mechanism of CPPs,and its application in anti-tumor therapy which hope to provide the reference of method and novel strategy for the identification of new CPPs and anti-tumor in clinical were summarized.
作者
卢钟腾
呼高伟
LU Zhong-teng;HU Gao-wei(School of Life Sciences,Taizhou Univesticy,Taizhou 318000,China)
出处
《中国生物工程杂志》
CAS
CSCD
北大核心
2019年第12期50-55,共6页
China Biotechnology
基金
台州学院校立科研培育项目(2018PY019)对新型细胞穿膜肽鉴定研究的支持
关键词
细胞穿膜肽鉴定
穿膜机制
抗肿瘤治疗的应用
Identification of CPPs
Penetrating mechanism
Application in anti-tumor therapy
