摘要
目的探究胺碘酮治疗心律失常的效果及对患者超敏C-反应蛋白水平、心率变异性指标的影响。方法回顾性分析2013年12月~2018年12月我院收治的68例心律失常患者的临床资料,按照不同的治疗方法将其分为实验组和对照组,每组各34例。对照组患者给予盐酸普罗帕酮治疗,实验组患者给予盐酸胺碘酮片治疗。比较两组患者的临床疗效、不良反应总发生率及治疗前后心功能指标(心率、左室射血分数)、血清超敏C-反应蛋白水平、心率变异参数[全部窦性心搏RR期间的标准差(SDNN)、RR间期差值均方根(rMSSD)、短期时间心跳间期平均标准偏差(SDANN)、RR间期的标准差(RR-SDANN)]。结果实验组患者的治疗总有效率高于对照组,差异有统计学意义(P<0.05)。两组患者治疗后的心率和血清超敏C-反应蛋白水平均低于治疗前,且实验组低于对照组,差异有统计学意义(P<0.05);两组患者治疗后的左室射血分数高于治疗前,且实验组高于对照组,差异有统计学意义(P<0.05)。两组患者治疗后的SDNN、rMSSD、SDANN、RR-SDANN均高于治疗前,且实验组高于对照组,差异有统计学意义(P<0.05)。两组患者的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论胺碘酮治疗心律失常患者的临床效果更加显著,能明显增强患者心功能,减轻炎症,增加心率变异参数。
Objective To explore the effect of Amiodarone in the treatment of arrhythmia and its influence on the level of hypersensitive C-reactive protein and heart rate variability in patients.Methods The clinical data of 68 patients with arrhythmia admitted to our hospital from December 2013 to December 2018 were retrospectively analyzed.According to different treatment methods,they were divided into experimental group and control group,with 34 cases in each group.Patients in the control group were treated with Propafenone Hydrochloride,and patients in the experimental group were treated with Amiodarone Hydrochloride Tablets.The clinical efficacy,total incidence rate of adverse reactions and cardiac function indexes(heart rate and left ventricular ejection fraction),serum hypersensitive C-reactive protein level,and heart rate variability parameters(standard diviation of NN intervals[SDNN],root mean square difference of RR interval[rMSSD],standard diviation average of NN intervals[SDANN],standard deviation of RR interval[RR-SDANN])before and after treatment were compared between the two groups.Results The total effective rate of treatment in the experimental group was higher than that in the control group,and the difference was statistically significant(P<0.05).The heart rate and serum hypersensitive C-reactive protein level of the two groups after treatment were lower than those before treatment,and those in the experimental group were lower than those in the control group,with statistically significant differences(P<0.05).The left ventricular ejection fraction of the two groups of patients after treatment was higher than that before treatment,and that in the experimental group was higher than that in the control group,the difference was statistically significant(P<0.05).After treatment,SDNN,rMSSD,SDANN,and RR-SDANN in the two groups were higher than those before treatment,and those in the experimental group were higher than those in the control group,the differences were statistically significant(P<0.05).There was no si
作者
罗培良
LUO Pei-liang(Department of Cardiovascular Medicine,People′s Hospital of Xinyi City,Guangdong Province,Xinyi525300,China)
出处
《中国当代医药》
2020年第4期59-62,共4页
China Modern Medicine
关键词
胺碘酮
普罗帕酮
心律失常
心率变异性
Amiodarone
Propafenone
Arrhythmia
Heart rate variability
