摘要
目的分析Tourette综合征患儿应用阿立哌唑治疗的临床疗效及安全性。方法将我院83例Tourette综合征患儿采用随机数字表法分组,对照组41例应用氟哌啶醇口服治疗,观察组42例应用阿立哌唑口服治疗,对比两组患儿治疗后症状变化、血清炎症因子水平、血清神经递质水平、焦虑抑郁评分、临床疗效及不良反应发生率。结果观察组的总有效率及YGTSS评分与对照组无明显差异(P>0.05);观察组的IL-8、IL-6、DA水平、SCARED、DSRSC评分及不良反应发生率均低于对照组,TNF-α、5-HT水平高于对照组(P<0.05)。结论阿立哌唑能够有效调节Tourette综合征患儿血清炎症因子及神经递质水平,改善抽动症状及情绪障碍,安全性高。
Objective To analyze the clinical efficacy and safety of aripipazole in children with Tourette syndrome.Methods 83 children with Tourette syndrome in our hospital were randomly divided into two groups.41 patients in the control group were treated with haloperidol orally,while 42 patients in the observation group were treated with aripiprazole orally.Changes,serum inflammatory factor levels,serum neurotransmitter levels,anxiety and depression scores,clinical efficacy,and incidence of adverse events between two groups were compared.Results There was no different in total effective rate and YGTSS score between two groups(P>0.05).The levels of IL-8,IL-6,DA,SCARED,DSRSC and adverse reactions in the observation group were lower than those in the control group.The levels ofαand 5-HT in the observation group were higher than those of the control group(P<0.05).Conclusion Aripiprazole can effectively regulate serum inflammatory factors and neurotransmitters in children with Tourette syndrome,improve tic symptoms and mood disorders with high safety.
作者
谢春良
缑志娟
王俊
刘钧菲
XIE Chunliang;GOU Zhijuan;WANG Jun(the People's Hospital of Hua County,Huaxian 456400,China)
出处
《国际精神病学杂志》
2019年第6期1027-1029,共3页
Journal Of International Psychiatry
