摘要
目的阿托伐他汀是治疗急性脑梗死有效药物,然而其效果发挥多具有剂量依赖性。本研究探讨阿托伐他汀强化降脂治疗对急性脑梗死患者近期疗效及颈动脉斑块状态影响。方法选取我院2017-01-01-2018-01-02收治的急性脑梗死患者为研究对象,按照性别、年龄、梗死特征等因素组间具有可比性的原则分组,其中常规组46例口服20mg阿托伐他汀治疗,强化组47例给予40mg阿托伐他汀口服治疗。对比治疗3个月末两组血脂、血液黏度、颈动脉斑块及预后情况。结果治疗3个月末,强化组和常规组低密度脂蛋白胆固醇水平分别为(1.64±0.36)和(1.81±0.53)mmol/L,t=1.813,P=0.037;高密度脂蛋白胆固醇水平分别为(1.42±0.28)和(1.22±0.27)mmol/L,t=3.505,P<0.001;总胆固醇水平分别为(3.24±0.41)和(3.47±0.69)mmol/L,t=1.959,P=0.027;血液黏度分别为(1.07±0.04)和(1.25±0.06)mPa/s,t=17.057,P<0.001。强化组和常规组斑块面积分别为(0.41±0.17)和(0.58±0.21)cm2,t=4.295,P<0.001;斑块Crouse积分分别为(2.24±0.68)和(3.07±0.61)mm,t=6.192,P<0.001;内膜-中层厚度分别为(1.21±0.29)和(1.47±0.33)mm,t=4.038,P<0.001;卒中量表评分分别为(7.94±0.61)和(9.82±1.51)分,t=7.903,P<0.001。强化组不良反应发生率为17.02%,常规组为10.87%,差异无统计学意义,χ^2=0.732,P=0.392。结论急性脑梗死患者采用40mg阿托伐他汀进行强化降脂治疗可改善其血脂水平及神经功能,降低血液黏度,稳定并一定程度上逆转动脉硬化斑块。
OBJECTIVE Atorvastatin is an effective drug for the treatment of acute cerebral infarction,but its effect is mostly dose-dependent.This study aims to investigate the effect of atorvastatin intensive lipid-lowering therapy on short-term efficacy and carotid plaque status in patients with acute cerebral infarction.METHODS The patients with acute cerebral infarction admitted to our hospital were enrolled in the study.The patients with acute cerebral infarction admitted to our hospital from January 1,2017to January 2,2018were selected as subjects according to the principle of sex,age,infarction characteristicsuc21 and other factors.Among them,46patients in the routine group received oral 20mg.In the atorvastatin treatment,47patients in the intensive group were given oral treatment with 40mg of atorvastatin.The blood lipid,blood viscosity,carotid plaque and prognosis of the two groups were compared at the end of 3rd month.RESULTS At the end of 3months of treatment,the level of low-density lipoprotein cholesterol in the intensive group and the conventional group were(1.64±0.36)and(1.81±0.53)mmol/L,t=1.813,P=0.037.The high-density lipoprotein cholesterol level were(1.42±0.28)and(1.22±0.27)mmol/L,t=3.505,P<0.001.The total cholesterol level were(3.24±0.41)and(3.47±0.69)mmol/L,t=1.959,P=0.027.The blood viscosity were(1.07±0.04)and(1.25±0.06),t=17.057,P<0.001.The plaque areas of the intensive group and the conventional group were(0.41±0.17)and(0.58±0.21)cm2,t=4.295,P<0.001.The plaque Crouse integrals were(2.24±0.68)and(3.07±0.61)mm,t=6.192,P<0.001.The intima-media thickness were(1.21±0.29)and(1.47±0.33)mm,t=4.038,P<0.001.The stroke scale scores were(7.94±0.61)and(9.82±1.51),t=7.903,P<0.001.The incidence of adverse reactions in the intensive group and the conventional group were 17.02%and 10.87%,there was no significant difference between the two groups,χ^2=0.732,P=0.392.CONCLUSION Intensive lipid-lowering therapy with atorvastatin in patients with acute cerebral infarction can improve blood lipid levels and
作者
李新梅
马金辉
LI Xin-mei;MA Jin-hui(Xunxian People's Hospital,Xunxian 456250,P.R.China)
出处
《社区医学杂志》
2019年第21期1342-1345,共4页
Journal Of Community Medicine
关键词
阿托伐他汀
急性脑梗死
强化降脂
颈动脉斑块
atorvastatin
acute cerebral infarction
intensive lipid lowering
carotid plaque
