摘要
目的探讨高血压与男性性功能障碍发病风险的关系。方法采用前瞻性队列研究方法,随机抽取2015年中国人民解放军联勤保障部队第九二三医院进行健康体检的30~40岁已婚男性1000例进行基线调查,实际调查892人,有效应答率89.2%,剔除不符合调查条件者78例,最终可纳入研究对象为814例。按基线调查有或无高血压情况分为高血压组和正常血压组。随后开展3年随访,并剔除在随访中新发影响性功能的器质性疾病者、随访期服用降压药者、失访者,共135例。最后可纳入数据统计分析共679例。采用Cox模型分析高血压与男性性功能障碍发病风险比及95%可信区间(95%CI)。结果高血压组177例(26.07%),正常血压组502例(73.93%)。开展3年随访发现高血压组患者的性功能障碍发生率为48.58%,明显高于正常血压组的15.54%,差异有统计学意义(P<0.05)。Cox回归单因素结果显示,高血压组性功能障碍发病风险是正常血压组的2.056倍;调整高血压患者的年龄、BMI、饮酒、吸烟、职业类型、夫妻关系、高血脂症史和糖尿病史因素后,Cox回归多因素分析结果显示,高血压组性功能障碍发病风险是正常血压组的3.133倍。结论高血压是增加男性性功能障碍发生风险的危险因素,临床中应密切关注男性高血压患者的情况,并及早采取措施预防或避免性功能障碍发生。
Objective To explore the relationship between hypertension and the risk of male sexual dysfunction.Methods A prospective cohort study was used to randomly select 1000 married men aged 30 to 40 who had undergone a health checkup at the No.923 Hospital of the Joint Service of the Chinese Peoples Liberation Army from January to December 2015.A baseline survey was performed on 892 people,with an effective response rate of 89.2%,78 patients who did not meet the survey conditions were excluded,and 814 patients could be included in the study.They were divided into hypertension group and normal blood pressure group according to baseline investigation with or without hypertension.Subsequently,a 3-year follow一up was conducted,and 135 patients with new organic disease affecting sexual function,those taking antihypertensive drugs during follow-up,and those who were lost to follow-up were excluded.A total of 679 cases can be included in the statistical analysis.The Cox model was used to analyze the risk ratio(HR)and 95%confidence interval(95%CI)of hypertension and male sexual dysfunction.Results There were 177 cases(26.07%)in the hypertension group and 502 cases(73.93%)in the normal blood pressure group.After 3 years of follow-up,the incidence of sexual dysfunction in the hypertension group was 4&58%,which was significantly higher than that in the normal blood pressure group of 15.54%.The difference was statistically significant(P<0.05).Cox regression univariate results showed that the risk of sexual dysfunction in the hypertension group was 2.056 times that of the normal blood pressure group;after adjusting the factors of age,BMI,drinking,smoking,occupation type,relationship between husband and wife,history of hyperlipidemia and diabetes,Cox regression analysis showed that the risk of sexual dysfunction in hypertension group was 3.133 times that of the normal blood pressure group.Conclusion Hypertension is a risk factor that increases the risk of male sexual dysfunction.In clinical practice,we should pay close attention to
作者
马利贤
莫增密
梁朝英
MA Li-xian;MO Zeng-mi;LIANG Chao-ying(Department of Cardiology,No.923 Hospital of the Joint Service of the Chinese Peoples Liberation Army,Nanning Guangxi 530021,P.R.China;Department of Andriatrics,No.923 Hospital of the Joint Service of the Chinese Peoples Liberation Army,Nanning Guangxi 530021,P.R.China;Physical Examination Center,No.923 Hospital of the Joint Service of the Chinese Peoples Liberation Army,Nanning Guangxi 530021,P.R.China)
出处
《中国计划生育和妇产科》
2020年第2期51-54,共4页
Chinese Journal of Family Planning & Gynecotokology
关键词
高血压
男性
性功能障碍
前瞻性队列研究
hypertension
male
sexual dysfunction
prospective cohort study
