摘要
目的研究泌尿系感染患儿病原菌的分布及对常用抗菌药物的敏感性情况,从而为临床合理使用抗菌药物提供科学依据。方法选取从2018年1至12月泌尿系感染患儿100例作为观察对象。采用法国生物梅里埃公司VITEK-compact检测患儿病原菌的分布情况,并进行病原菌的药敏试验。结果100例泌尿系感染患儿病原菌分布情况按照占比从高到低依次为大肠埃希菌51.00%、肺炎克雷伯菌12.00%、粪肠球菌10.00%、屎肠球菌7.00%、铜绿假单胞菌4.00%、奇异变形杆菌3.00%、摩氏摩根菌2.00%、金黄色葡萄球菌1.00%和白色假丝酵母菌1.00%。大肠埃希菌对哌拉西林、阿莫西林克拉维酸、哌拉西林他唑巴坦、头孢噻肟、头孢他啶和亚胺培南的耐药率分别为70.59%、5.88%、3.92%、41.18%、31.37%和0。肺炎克雷伯菌对哌拉西林、阿莫西林克拉维酸、哌拉西林他唑巴坦、头孢噻肟、头孢他啶和亚胺培南的耐药率分别为41.67%、25.00%、16.67%、33.33%、16.67%和0。粪肠球菌对氨苄西林、庆大霉素、环丙沙星、呋喃妥因、利奈唑胺和万古霉素的耐药率分别为10.00%、40.00%、30.00%、0、10.00%和0。结论泌尿系感染患儿病原菌主要以大肠埃希菌、肺炎克雷伯菌、粪肠球菌为主,其中大肠埃希菌、肺炎克雷伯菌均对亚胺培南有较高的敏感性,粪肠球菌对呋喃妥因、万古霉素的敏感性较高,值得临床重点关注。
AIM To study the distribution of pathogenic bacteria and the sensitivity of antimicrobial agents in children with urinary tract infection,so as to provide scientific basis for rational use of antimicrobial agents in clinical practice.METHODS Totally 100 cases of children with urinary tract infection from January 2018 to De-cember 2018 were selected as observation objects.VITEK-compact was used to detect the distribution of pathogenic bacteria in children.The drug sensitivity test of pathogen was also carried out.RESULTS Totally 100 cases of children with urinary tract infection pathogens distribution according to proportion order from high to low,respec-tively,51.00%of Escherichia coli,12.00%of Klebsiella pneumonia,10.00%of Enterococcus faecalis,7.00%of Excrement enterococcus,4.00%of Pseudomonas aeruginosa,3.00%of Singular proteus,2.00%of mohs Morgan bacteria,1.00%of Staphylococcus aureus,and 1.00%of White candida.The drug resistance rates of Escherichia coli to piperacillin,amoxicillin/clavulanic acid,piperacillin/tazobactam,cefotaxime,ceftazidime and imipenem were 70.59%,5.88%,3.92%,41.18%,31.37%and 0,respectively.The drug resistance rates of Klebsiella pneumoniae to piperacillin,amoxicillin/clavulanic acid,piperacillin/tazobactam,cefotaxime,ceftazidime and imipenem were 41.67%,25.00%,16.67%,33.33%,16.67%and 0,respectively.The drug resistance rates of Enterococcus faecalis to ampicillin,gentamicin,ciprofloxacin,furantoin,linidazole and vancomycin were 10.00%,40.00%,30.00%,0,10.00%and 0,respectively.CONCLUSION Escherichia coli,Klebsiella pneumonia and Enterococcus faecalis are the main pathogenic bacteria in children with urinary tract infection,and Escherichia coli and Klebsiella pneumoniae are both highly sensitive to imipenem,but Enterococcus faecalis is highly sensitive to furantoin and vancomycin.It is worthy of clinical attention.
作者
罗小昆
孙丽
何玥
LUO Xiaokun;SUN Li;HE Yue(Department of Pharmacy,Shajing Peoples'Hospital,Baoa'n District,Shenzhen City,Guangdong Province,Shenzhen 518104,China)
出处
《中国临床药学杂志》
CAS
2020年第1期35-37,共3页
Chinese Journal of Clinical Pharmacy
基金
深圳市宝安区科技计划社会公益项目(编号2016CX150)
关键词
泌尿系感染
病原菌
抗菌药物
敏感性
urinary tract infection
pathogenic bacteria
antimicrobial agent
sensitivity
