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干燥综合征及其相关间质性肺病患者血清25羟维生素D3水平及临床意义 被引量:3

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摘要 目的:探讨干燥综合征(SS)及其相关间质性肺病(ILD)患者血清25羟维生素(25-OH-V)D3水平变化和临床意义。方法:原发性SS患者62例,其中合并ILD 16例(SS-ILD组),未合并ILD46例(SS-NILD组),另设健康对照组25例。比较各组血清25-OH-VD3水平,分析SS患者血清25-OH-VD3水平与实验室指标的相关性,以及SS-ILD患者血清25-OH-VD3水平与肺功能的相关性。结果:血清25-OH-VD3水平SS-ILD组为12.36±3.46 ng/mL,SS-NILD组为15.08±3.46 ng/mL,健康对照组为19.36±5.44 ng/mL,SS-ILD组(P<0.01)、SS-NILD组(P<0.05)低于健康对照组,SS-ILD组低于SS-NILD组(P<0.05),差异均有统计学意义。SS患者血清25-OH-VD3水平与血沉(r=-0.398)、IgG(r=-0.296)、SSDAI评分(r=-0.353)负相关(P<0.05)。SS-ILD患者血清25-OH-VD3水平与FVC%(r=0.625)、DLCO(r=0.569)正相关(P<0.05)。结论:血清25羟维生素D3水平与干燥综合征的病情活动及合并间质性肺病患者的肺功能明显相关,在疾病病情评估中具有一定价值。
作者 任云丽
出处 《交通医学》 2020年第1期32-33,36,共3页 Medical Journal of Communications
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