摘要
Glaucoma,"a silent thief of sight"and the leading cause of irreversible blindness,ischaracterizedbyretinalganglioncell(RGC)deathand optic nerve degeneration.Elevation of intraocular pressure(IOP),also called ocular hypertension,is the most recognized risk factor for glaucoma(Jonasetal.,2017).Currenttherapiesonlytargetreductionof IOP,but irreversible RGC death continues even after IOP is normalized(Wormald et al.,2020),indicating the critical clinical need to prevent degeneration and/or replace lost RGCs.
