摘要
目的探讨UNC-51样激酶1(ULK1)在结直肠癌组织中的表达及临床意义。方法选择德清县人民医院外科和浙江大学附属邵逸夫医院外科手术治疗的结直肠癌患者200例,采用免疫组化法测定结直肠癌组织和癌旁组织中ULK1蛋白表达情况,分析ULK1蛋白与结直肠癌患者临床病理特点及预后的关系。结果结直肠癌组织中ULK1蛋白阳性率(65.50%)低于癌旁组织(37.50%)(P<0.05)。ULK1蛋白与结直肠癌的TNM分期、分化程度、淋巴结转移和远处转移有关(P<0.05),与年龄、性别、肿瘤的脉管侵犯、浸润深度、直径无关(P<0.05)。结直肠癌患者的5年总生存率为54.32%,ULK1阴性表达患者的5年生存率为67.53%,ULK1阳性表达患者的5年生存率位46.75%,ULK1阴性表达患者的生存时间高于ULK1阳性表达患者(P<0.05)。结论ULK1在结直肠癌组织中呈高表达,ULK1阳性表达患者预后差。
Objective To investigate the expression and clinical significance of UNC-51-like kinase 1(ULK1)in colorectal cancer tissues.Methods 200 patients with colorectal cancer who underwent surgical treatment inDeqing County People's Hospital and Shaoyifu Hospital affiliated to Zhejiang University were selected.The immunohistochemistry was used to determine the expression of ULK1 protein in colorectal cancer tissues and adjacent tissues.The relationship between ULK1 protein and clinicopathological features and prognosis in patients with colorectal cancerwas analyzed.Results The positive rate of ULK1 protein in colorectal cancer tissues(65.50%)was lower than that in adjacent tissues(37.50%)(P<0.05).The ULK1 protein was associated with TNM stage,degree of differentiation,lymph node metastasis and distant metastasis of colorectal cancer(P<0.05),and it was not related to age,gender,vascular invasion,depth of invasion,and diameter of colorectal cancer(P<0.05).The 5-year overall survival rate of all patients with colorectal cancer was 54.32%.The 5-year survival rate of patients with negative expression of ULK1 was 67.53%.The 5-year survival rate of patients with positive expression of ULK1 was 46.75%.The survival time of patients with ULK1negative expression was higher than that of patients with ULK1 positive expression(P<0.05).Conclusion ULK1 is highly expressed in colorectal cancer tissues,and patients with positive expression of ULK1 have poor prognosis.
作者
倪文文
王先法
NI Wenwen;WANG Xianfa(Deqing County People's Hospital.Zhejiang 313200,China;不详)
出处
《浙江创伤外科》
2020年第1期3-6,共4页
Zhejiang Journal of Traumatic Surgery
