摘要
目的探讨血清胱抑素C(Cys C)与视黄醇结合蛋白(RBP)在高血压与非高血压早期未破裂的脑动脉瘤患者诊断中的应用价值。方法采用美国贝克曼库尔特AU5811全自动生化分析仪对本院2015年9月~2018年12月确诊的149例高血压早期未破裂脑动脉瘤患者,121例非高血压未破裂的脑动脉瘤患者及200例正常体检的健康者进行Cys C与RBP检测。结果高血压早期未破裂的脑动脉瘤患者血清Cys C(2.98±0.65)ρ/mg·L-1和RBP水平(104.31±18.00)ρ/mg·L-1与对照组差异明显(P<0.05),非高血压早期未破裂的脑动脉瘤患者血清Cys C和RBP水平与对照组无明显差异(P>0.05),高血压早期脑动脉瘤患者血清水平血清Cys C(2.97±0.61)ρ/mg·L-1和RBP水平(104.68±16.40)ρ/mg·L-1与非高血压早期脑动脉瘤患者有明显差异(P<0.05),早期未破裂的脑动脉瘤与高血压在同时存在的患者血清Cys C和RBP升高,非高血压早期未破裂的脑动脉瘤患者血清Cys C和RBP变化不明显。结论在高血压与早期未破裂的脑动脉瘤同时存在患者诊断中,血清Cys C和RBP水平的变化可为临床早期诊断提供实验室依据。
Objective To explore the value of serum cystatin C(Cys C) and retinol binding protein(RBP) in the diagnosis of patients with cerebral aneurysms without hypertension and non-hypertension. Methods One hundred and forty-nine patients with early-stage unruptured cerebral aneurysms diagnosed with hypertension from September 2015 to December 2018,121 patients with non-hypertensive unruptured cerebral aneurysms patients and 200 healthy subjects who underwent normal physical examination were tested for Cys C and RBP. Results Serum Cys C(2.98±0.65) ρ/mg·L-1 and RBP levels(104.31±18.00) ρ/mg·L-1 in patients with unruptured cerebral aneurysms in early stage of hypertension were significantly different from those in the control group(P<0.05). Serum Cys C and RBP levels in patients with non-hypertensive early ruptured cerebral aneurysms were not significantly different from those in the control group(P>0.05). Serum levels of serum Cys C(2.97±0.61) ρ/mg·L-1 in patients with early cerebral aneurysms of hypertension and RBP levels(104.68±16.40) ρ/mg·L-1 were significantly different from those of non-hypertensive early cerebral aneurysms(P<0.05). Early unruptured cerebral aneurysms and hypertension were present at the same time. Serum Cys C and RBP were elevated in patients, and serum Cys C and RBP were not significantly altered in patients with non-hypertensive early ruptured cerebral aneurysms. Conclusion Changes in serum Cys C and RBP levels can provide a laboratory basis for early clinical diagnosis in patients with hypertension and early unruptured cerebral aneurysms.
作者
杨秀静
王兴业
高勇
孙士明
周亚丹
杜欣
朱月平
YANG Xiu-jing;WANG Xing-ye;GAO Yong;SUN Shi-ming;ZHOU Ya-dan;DU Xin;ZHU Yue-ping(Department of Clinical Laboratory,The Third Affiliated Hospital of Qiqihar,Qiqihar 161091,China)
出处
《哈尔滨医科大学学报》
CAS
2019年第5期497-500,共4页
Journal of Harbin Medical University
基金
黑龙江省教育厅基本科研业务费基础研究项目资助(2016-KYYWF-0872)
关键词
未破裂
动脉瘤
高血压
血清胱抑素C
视黄醇结合蛋白
early unruptured cerebral aneurysm
hypertension
serum cystatin C
retinol binding protein
