摘要
阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome,OS-AHS)作为多种心血管疾病的独立危险因素,可增加心律失常、高血压及冠心病等多种心血管疾病的患病率及死亡率。间歇性低氧和高碳酸血症、氧化应激和慢性炎症反应、交感迷走神经失衡、胸腔内压力改变、神经体液因子的激活等都是OSAHS诱发各种心血管疾病可能的病理生理机制。因此,及早发现OSAHS及其所导致的心血管疾病,有助于早期诊断和及时有效地干预。本文主要就OSAHS与心律失常、高血压、冠心病及心衰等疾病的关系予以阐述。
As an independent risk factor for a variety of cardiovascular diseases,obstructive sleep apnea hypopnea syndrome(OSAHS)can increase the prevalence and mortality of various cardiovascular diseases such as hypertension,coronary heart disease and arrhythmia.Intermittent hypoxia and hypercapnia,oxidative stress and chronic inflammatory response,sympathetic vagal imbalance,intrathoracic pressure changes,activation of neurohumoral factors,etc.are potential pathophysiological mechanisms of OSAHS-induced cardiovascular diseases.Early detection of OSAHS and its related cardiovascular diseases is helpful for early diagnosis and effective intervention.This article mainly describes the relationship among OSAHS and arrhythmia,hypertension,coronary heart disease and heart failure.
作者
穆热提·阿卜迪肖库尔
冯艳
Mureti Abudixiaokuer;Feng Yan(Postgraduate College of Xinjiang Medical University,Urumqi Xinjiang 830011;Department of Electrocardiogram,People's Hospital of Xinjiang Uygur Autonomous Region,Urumqi Xinjiang 830001,China)
出处
《实用心电学杂志》
2020年第1期59-65,共7页
Journal of Practical Electrocardiology
关键词
阻塞性睡眠呼吸暂停低通气综合征
心律失常
高血压
冠心病
心衰
obstructive sleep apnea hypopnea syndrome
arrhythmia
hypertension
coronary heart disease
heart failure
