摘要
目的探讨SOX联合阿帕替尼新辅助治疗方案对局部晚期胃癌手术的影响。方法选取2015年3月至2017年2月在本院择期进行手术治疗的局部晚期胃癌患者92例,根据随机数表法分为观察组和对照组,各46例。对照组采用SOX治疗方案,观察组采用SOX联合阿帕替尼新辅助治疗方案,随访2年。对比两组治疗效果、手术情况及存活情况。结果观察组临床缓解率及手术切除率均高于对照组,差异有统计学意义(P<0.05);观察组术后1年、2年存活率均高于对照组,差异有统计学意义(P<0.05)。结论SOX联合阿帕替尼新辅助治疗方案可有效提高局部晚期胃癌患者手术切除率,提高治疗效果及存活率。
Objective To investigate the effect of SOX combined with abatatinib neoadjuvant therapy on locally advanced gastric cancer surgery.Methods A total of 92 patients with locally advanced gastric cancer who underwent elective surgery in our hospital from March 2015 to February 2017 were enrolled.According to the random number table method,they were divided into the control group and the observation group,with 46 cases in each group.The control group was treated with SOX,and the observation group was treated with SOX combined with a new adjuvant therapy with apatinib for 2 years.Compared to the treatment effects,surgical conditions and survival of the two groups.Results The clinical remission rate and surgical resection rate of the observation group were higher than those of the control group,the difference was statistically significant(P<0.05).The survival rate of the observation group was higher than that of the control group at 1 year and 2 years after operation,the difference was statistically significant(P<0.05).Conclusion The new adjuvant therapy with SOX combined with apatinib can effectively improve the surgical resection rate and improve the treatment effect and survival rate of patients with locally advanced gastric cancer.
作者
孟雷
蔡善保
Meng Lei;Cai Shanbao(Department of General Surgery,Xinxiang Medical College,Xinxiang,Henan,453003,China;Department of Orthopaedics,Anhui Cancer Hospital,Hefei,Anhui,230031,China)Abstract:Objective To investigate the effect of SOX combined with abatatinib neoadjuvant therapy)
出处
《当代医学》
2020年第6期62-64,共3页
Contemporary Medicine
关键词
局部晚期胃癌
阿帕替尼
SOX方案
手术切除率
存活
Locally advanced gastric cancer
Apatinib
SOX regimen
Surgical resection rate
Survival
