摘要
目的探讨调肝运脾法联合美沙拉嗪缓释颗粒治疗腹泻型肠易激综合征(IBS-D)的临床疗效。方法 2016年9月至2017年11月诊治的200例IBS-D患者根据随机数字表法分为两组,各100例。对照组采用美沙拉嗪缓释颗粒治疗,观察组采用调肝运脾法联合美沙拉嗪缓释颗粒治疗,疗程2周。比较两组疗效、IBS症状严重程度量表(IBS-SSS)、IBS生活质量量表(IBS-QOL)评分的差异。结果观察组临床治愈率(51. 00%vs 35. 00%,P=0. 022)、总有效率(98. 00%vs 81. 00%,P=0. 000)均高于对照组;观察组治疗后IBS-SSS评分由(261. 04±76. 08)降到(122. 81±13. 81),治疗前后差异具有统计学意义(P=0. 000),且观察组治疗后低于对照组治疗后(P=0. 000);观察组治疗后除自体意象外IBS-QOL各维度评分显著低于治疗前(P均<0. 01),且IBS-QOL所有维度评分观察组治疗后均低于对照组治疗后(P均<0. 01)。结论调肝运脾法联合美沙拉嗪缓释颗粒治疗IBS-D效果优于美沙拉嗪。
Objective To explore the clinical efficacy of Tiaogan Yunpi method combined with mesalazine sustainedrelease granules on diarrhea-predominate irritable bowel syndrome( D-IBS). Methods Total 200 patients with D-IBS were divided into two groups according to the random number table method from September 2016 to November 2017. The control group( n = 100) was treated with mesalazine sustained-release granules,and the observation group( n = 100) was treated with Tiaogan Yunpi method combined with mesalazine sustained-release granules. The course of treatment was 2 weeks,and the differences in the efficacy,IBS Symptom Severity Scale( IBS-SSS),and IBS Quality of Life Scale( IBS-QOL) scores were compared between the two groups. Results The cure rate( 51. 00% vs 35. 00%,P = 0. 022) and total effective rate( 98. 00% vs 81. 00%,P = 0. 000) in the observation group were higher than those in the control group. After treatment,the IBS-SSS score of the observation group decreased from( 261. 04 ± 76. 08) to( 122. 81 ± 13. 81)( P < 0. 01),and was lower than that of the control group. Except for self-intention,the scores of other dimensions of IBS-QOL in the observation group after treatment were significantly lower than those before treatment( all P < 0. 01),and the scores of all dimensions of IBSQOL in the observation group after treatment were lower than those in the control group( all P < 0. 01). Conclusion Tiaogan Yunpi method combined with mesalazine sustained-release granules is better than mesalazine in treating diarrheatype irritable bowel syndrome.
作者
徐文慧
李磊
XU Wen-hui;LI Lei(The Second Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing,Jiangsu 210017,China)
出处
《中国临床研究》
CAS
2020年第1期98-101,共4页
Chinese Journal of Clinical Research
基金
江苏省研究生科研与实践创新计划项目(SJCX18_0457)~~
关键词
调肝运脾法
美沙拉嗪缓释颗粒
肠易激综合征
腹泻型
Tiaogan Yunpi method
Mesalazine sustained-release granules
Irritable bowel syndrome,diarrhea type
