摘要
Klotho(KL)蛋白是一种主要在肾脏及大脑中表达的膜结合蛋白,可通过调控离子通道、转化生长因子(transforming growth factor,TGF)等多个信号通路和靶基因的表达,发挥抗衰老、肾脏保护、抗肿瘤和调节代谢等作用。新近研究发现,KL蛋白在肾间质纤维化(renal interstitial fibrosis,RIF)等肾脏疾病中发挥重要作用,KL基因缺陷可诱导和促进RIF进展,KL过表达或补充可防止RIF,该文就KL蛋白通过多种信号通路发挥抗RIF作用作一综述,旨在为抗RIF治疗提供新的方向。
Klotho(KL)protein is a membrane-bound protein mainly expressed in the kidney and brain.It can regulate the expression of multiple signal pathways and target genes,such as ion channels,transforming growth factor(TGF),and exert anti-aging effects,kidney protection,anti-tumor and regulating metabolism.Recent studies have found that KL protein plays an important role in renal diseases such as renal interstitial fibrosis(RIF).KL deficiency can induce and promote the progress of RIF,and KL overexpression or supplementation can prevent RIF.This review focuses on the anti-RIF effect of KL protein through multiple signaling pathways,and aims to provide a new direction for anti-RIF therapy.
作者
杨园园(综述)
姜红
李维(审校)
Yang Yuanyuan;Jiang Hong;Li Wei(Department of Pediatrics,The First Affiliated Hospital of China Medical University,Shenyang 110001,China)
出处
《国际儿科学杂志》
2019年第12期919-922,共4页
International Journal of Pediatrics
