摘要
目的探讨进展性缺血性脑卒中(PIS)患者的危险因素及微栓子对进展性卒中的预测价值。方法纳入2016年3月至2018年3月就诊于内蒙古自治区人民医院神经内科的50例PIS患者及同时期非进展的缺血性卒中病人62例,所有纳入的患者均行头颅磁共振、颈动脉血管超声、心脏彩超、心电图、48 h内微栓子检查,并对纳入的患者进行问卷调查。结果微栓子阳性PIS患者病灶多位于皮质(P<0.05)。PIS与微栓子、低密度脂蛋白异常、院前未服用阿司匹林、院前服用降压药物、颈动脉斑块等因素显著相关(P<0.05)。logistic回归分析提示微栓子(OR=7.246,P=0.001)、低密度脂蛋白异常(OR=3.879,P=0.007)、颈动脉斑块(OR=4.177,P=0.007)、院前未口服阿司匹林(OR=4.304,P=0.046)、院前服用降压药物(OR=3.734,P=0.01)为PIS的独立危险因素。结论微栓子、低密度脂蛋白异常、院前未口服阿司匹林、院前服用降压药物、颈动脉斑块是PIS危险因素,且微栓子更具预测价值。
Objective To investigate the risk factors for progressive ischemic stroke(PIS)and the value of microemboli in predicting progressive stroke.Methods A total of 50 patients with PIS and 62 patients with non-progressive ischemic stroke(NPIS)who were admitted to Department of Neurology,Inner Mongolia People's Hospital,from March 2016 to March 2018 were enrolled.All patients underwent cranial magnetic resonance imaging,carotid artery ultrasound,echocardiography,electrocardiography,and microembolic signal monitoring within 48 hours,and a questionnaire survey was performed for all patients.Results Most of the lesions in PIS patients with microemboli were located in the cortex(P<0.05).PIS was significantly associated with microemboli,abnormal low-density lipoprotein,no administration of aspirin before admission,administration of antihypertensive drugs before admission,and carotid plaque(P<0.05).The logistic regression analysis showed that microemboli(odds ratio[OR]=7.246,P=0.001),abnormal low-density lipoprotein(OR=3.879,P=0.007),carotid plaque(OR=4.177,P=0.007),no administration of aspirin before admission(OR=4.304,P=0.046),and administration of antihypertensive drugs before admission(OR=3.734,P=0.01)were independent risk factors for PIS.Conclusions Microemboli,abnormal low-density lipoprotein,no administration of aspirin before admission,administration of antihypertensive drugs before admission,and carotid plaque are the risk factors for PIS,and microemboli have a certain predictive value.
作者
陈金
姚远
朱润秀
CHEN Jin;YAO Yuan;ZHU Run-Xiu(Department of Neurology,Inner Mongolia People's Hospital,Huhehaote 010010,China)
出处
《国际神经病学神经外科学杂志》
2019年第6期614-617,共4页
Journal of International Neurology and Neurosurgery
基金
内蒙古自治区卫生计生科研计划项目(20170318)
内蒙古自治区人民医院院内基金项目(2016100)
关键词
进展性缺血性脑卒中
微栓子
危险因素
progressive ischemic stroke
microembolic signal
risk factor
