摘要
目的观察基于气血理论运用益气活血方法干预高血压左室舒张功能障碍的临床疗效。方法将前期横断面调查中筛选出的高血压病心脏舒张功能障碍病人随机分配进入对照组、原方案组、优化方案组。对照组采用基础治疗加中药安慰剂,原方案组采用基础治疗加眩晕(原发性高血压)中医诊疗方案“补肾降压方”,优化方案组为原方案加益气活血方,治疗8周,随访6个月,评价中医药防治高血压病心脏舒张功能障碍的临床疗效。结果治疗后,优化方案组舒张早期二尖瓣峰值血流速度/舒张早期二尖瓣环运动峰值速度(E/Ea)比值较治疗前明显下降,差异有统计学意义(P<0.01),且优化方案组E/Ea比值低于对照组、原方案组,差异均有统计学意义(P<0.05或P<0.01);优化方案组治疗后头晕、双目干涩、肢体麻木、胫酸膝软、五心烦热、潮热盗汗、耳鸣、口干咽燥、便秘、神疲、乏力、懒言、失眠、瘀血等症状评分较治疗前均明显降低(P<0.01)。与原方案组治疗后相比,优化方案组神疲、乏力、懒言、失眠、瘀血症状评分均明显降低(P<0.05或P<0.01)。与对照组治疗后相比,优化方案组双目干涩、胫膝酸软、潮热盗汗、口干咽燥、神疲、失眠、瘀血等症状评分均明显降低(P<0.05或P<0.01)。结论益气活血补肾降压方能降低高血压左室舒张功能障碍病人的E/Ea比值,可改善左室舒张期充盈,进而改善高血压左室舒张功能障碍,同时能改善高血压病人的临床症状,从而提高生活质量。
Objective To observe the clinical effect of qi-nourishing and blood-activating therapy on diastolic dysfunction in hypertension based on qi and blood theory.Methods The hypertensive patients with cardiac diastolic dysfunction selected from the previous cross-sectional survey were randomly assigned to the western medicine control group,the traditional Chinese medicine(TCM)program group,and the TCM optimization program group.The patients in western medicine control group were treated with the basic treatment plus TCM placebo.The patients in the TCM program group were treated with the basic treatment plus Bushen Jiangya decoction.The patients in the TCM optimization program group were treated with Yiqi Huoxue decoction in the basis of the basic treatment for 8 weeks,with 6 months of follow-up.The clinical curative effect was evaluated.Results After treatment,the E/Ea ratio in the TCM optimization program group was significantly lower than that before the treatment(P<0.01),which was lower than that in the western medicine control group and the TCM program group(P<0.05 or P<0.01).After treatment,the scores of symptoms were decreased in the TCM optimization program group compared with that before treatment(P<0.01).Compared with the original treatment group,the scores of symptoms such as fatigue,laziness,insomnia,and blood stasis were significantly reduced in the TCM optimization program group(P<0.05 or P<0.01).Compared with the control group,the scores of symptoms such as dry eyes,soft tibia and knees,night sweats,dry mouth and throat,fatigue,insomnia,and blood stasis were significantly lower than those in the TCM optimization program group(P<0.05 or P<0.01).Conclusion Yiqi Huoxue Bushen Jiangya decoction can reduce the E/Ea ratio in patients with hypertension and left ventricular diastolic dysfunction,improve left ventricular diastolic dysfunction and the clinical symptoms,thereby improving the quality of life.
作者
崔晓云
李品慧
范文英
逯金金
刘静
董巧稚
林谦
CUI Xiaoyun;LI Pinhui;FAN Wenying;LU Jinjin;LIU Jing;DONG Qiaozhi;LIN Qian(Dongfang Hospital,Beijing University of Chinese Medicine,Beijing 100078,China)
出处
《中西医结合心脑血管病杂志》
2019年第24期3881-3886,共6页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
基金
国家中医临床研究基地业务建设科研专项(No.JDZX2012106)
国家自然科学基金课题(No.81774044)
关键词
高血压
左室舒张功能障碍
益气活血方
中医证候
眩晕
hypertension
left ventricular diastolic dysfunction
Yiqi-nourishing and blood-activating therapy
traditional Chinese medicine syndromes
dizziness
