摘要
目的系统评价依达拉奉联合丹参注射液治疗急性脑梗死的疗效及安全性。方法检索CNKI、Wanfang、VIP、CMB、Pubmed、Embase、The Cochrane Library数据库,检索时限为从建库至2019年8月。按照纳排标准选择符合要求的随机对照试验(RCT),对纳入文献进行质量评价,采用Rev Man 5. 3软件对提取数据进行统计学分析。结果共纳入12篇文献,13项研究。结果显示:与对照组相比,依达拉奉联合丹参注射液治疗急性脑梗死可显著提高有效率[OR=5. 56,95%CI(3. 43,9. 00),Z=6. 98(P <0. 00001)],降低NIHSS评分[MD=-5. 90,95%CI(-8. 61,-3. 18),Z=4. 25 (P <0. 0001)]和CSS评分[MD=-6. 26,95%CI(-8. 51,-4. 01),Z=5. 46 (P <0. 00001)],提高ADL评分[MD=20. 81,95%CI(16. 82,24. 79),Z=10. 23 (P <0. 00001)],降低Hcy水平[MD=-2. 59,95%CI(-3. 34,-1. 84),Z=6. 74 (P <0. 00001)],缩小脑梗死体积[MD=-4. 40,95%CI (-4. 85,-3. 96),Z=19. 50(P <0. 00001)]。而在不良反应方面,两组无明显差异[OR=2. 20,95%CI(0. 88,5. 47),Z=1. 69(P=0. 09> 0. 05)]。结论依达拉奉联合丹参注射液治疗急性脑梗死能显著提高临床疗效,改善神经功能,提高生活质量,降低Hcy水平,缩小脑梗死体积,且临床应用安全。
Objective To systematically evaluate the efficacy and safety of edaravone combined with Salvia miltiorrhiza injection in the treatment of acute cerebral infarction. Methods CNKI,Wanfang,VIP,CMB,Pubmed,Embase and Cochrane Library databases were searched from establishment to August 2019. Randomized controlled trials( RCTs) were selected according to the inclusion and exclusion criteria,and the quality of the included literatures was evaluated. Statistical analysis of the extracted data was conducted by Rev Man 5. 3. Results 12 literatures and 13 studies were included. The results showed that: compared with the control group,edaravone combined with Salvia miltiorrhiza injection could significantly improve the effective rate[OR = 5. 56,95% CI( 3. 43,9. 00),Z = 6. 98( P < 0. 00001) ],reduce the NIHSS score [MD=-5. 90,95% CI(-8. 61,-3. 18),Z = 4. 25( P < 0. 0001) ]and CSS score[MD =-6. 26,95% CI(-8. 51,-4. 01),Z = 5. 46( P < 0. 00001) ],improve the ADL score [MD = 20. 81,95% CI( 16. 82,24. 79),Z = 10. 23( P < 0. 00001) ],reduce Hcy level [MD =-2. 59,95% CI(-3. 34,-1. 84),Z = 6. 74( P < 0. 00001) ],and cerebral infarction volume[MD =-4. 40,95% CI(-4. 85,-3. 96),Z = 19. 50( P < 0. 00001) ]. In terms of adverse reactions,there was no significant difference between the two groups[OR = 2. 20,95% CI( 0. 88,5. 47),Z = 1. 69( P = 0. 09 > 0. 05) ]. Conclusion Edaravone combined with Salvia miltiorrhiza injection can significantly improve the clinical efficacy,neurological function and the quality of life,reduce the level of Hcy and the volume of cerebral infarction,and is safe.
作者
孔静敏
朱杉杉
刘长英
刘若凡
王兆忻
张根明
KONG Jingmin;ZHU Shanshan;LI Changying(Dongzhimen Hospital,Beijing University of Traditional Chinese Medicine,Beijing 100100,China)
出处
《中风与神经疾病杂志》
CAS
2019年第11期1025-1029,共5页
Journal of Apoplexy and Nervous Diseases
基金
国家中医药管理局国家中医临床研究基地业务建设科研专项课题(JDZX2015050)
关键词
依达拉奉
丹参注射液
急性脑梗死
META分析
Edaravone
Salvia miltiorrhiza injection
Acute cerebral infarction
Meta-analysis
